Publications by authors named "Isabella Abramovna Khrapunova"
Comparison of Post-Vaccination Cellular Immune Response in Patients with Common Variable Immune Deficiency.
Aristitsa Mikhailovna Kostinova Elena Alexandrovna Latysheva Mikhail Petrovich Kostinov Nelly Kimovna Akhmatova Svetlana Anatolyevna Skhodova Isabella Abramovna Khrapunova
Vaccines (Basel)
July 2024
Article Synopsis
- The study investigates how one or two doses of inactivated adjuvanted influenza vaccines affect immune responses, specifically focusing on the expression of endosomal Toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID).
- Six CVID patients received one vaccine dose followed by nine patients who received two doses; flow cytometry was used to analyze immune cell populations and TLR expression.
- Findings show that while key lymphocyte populations remained stable post-vaccination, patients receiving two doses exhibited increased TLR3 and TLR9 expression, indicating that two-dose vaccine regimens may enhance immune responses in CVID patients.