Degradation of Structurally Defined Graphene Nanoribbons by Myeloperoxidase and the Photo-Fenton Reaction.

As an emerging member of the graphene family, structurally defined graphene nanoribbons (GNRs) have shown promising applications in various fields. The evaluation of the degradability of GNRs is particularly important for assessing the persistence level and risk of these materials in living organisms and the environment. However, there is a void in the study of the degradation of GNRs.

Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe-by-Design.

Safety assessment of graphene-based materials (GBMs) including graphene oxide (GO) is essential for their safe use across many sectors of society. In particular, the link between specific material properties and biological effects needs to be further elucidated. Here, the effects of lateral dimensions of GO sheets in acute and chronic pulmonary responses after single intranasal instillation in mice are compared.

Strategies for the Controlled Covalent Double Functionalization of Graphene Oxide.

Graphene oxide (GO) is a versatile platform with unique properties that have found broad applications in the biomedical field. Double functionalization is a key aspect in the design of multifunctional GO with combined imaging, targeting, and therapeutic properties. Compared to noncovalent functionalization, covalent strategies lead to GO conjugates with a higher stability in biological fluids.

Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity.

Graphene oxide (GO) is an oxidised form of graphene that has attracted commercial interest in multiple applications, including inks, printed electronics and spray coatings, which all raise health concerns due to potential creation of inhalable aerosols. Although a number of studies have discussed the toxicity of GO sheets, the in vivo impact of their lateral dimensions is still not clear. Here, we compared the effects of large GO sheets (l-GO, 1-20 µm) with those of small GO sheets (s-GO, < 1 µm) in terms of mesothelial damage and peritoneal inflammation, after intraperitoneal (i.

Chemical reactivity of graphene oxide towards amines elucidated by solid-state NMR.

Graphene oxide (GO) is an attractive nanomaterial for many applications. Controlling the functionalization of GO is essential for the design of graphene-based conjugates with novel properties. But, the chemical composition of GO has not been fully elucidated yet.

Different chemical strategies to aminate oxidised multi-walled carbon nanotubes for siRNA complexation and delivery.

In this work, we have investigated the preparation of amino-functionalised multi-walled carbon nanotubes (MWCNTs) as potential carriers for the delivery of siRNA. Several studies have shown promising results exploiting functionalised CNTs for the delivery of genetic material in vitro and in vivo. Our groups have previously observed that the type of surface functionalisation used to modify oxidised MWCNTs (oxMWCNTs) can lead to significant differences in nanotube cellular uptake and delivery capability.