Publications by authors named "Isabell Kondla"
Article Synopsis
- Immune checkpoint molecules like HVEM are important in understanding cancer prognosis and treatment, particularly in malignant diseases such as acute myeloid leukemia (AML).
- This study analyzed HVEM expression in bone marrow cells from 169 AML patients using flow cytometry and mRNA expression in 512 additional patients, revealing association between HVEM levels and certain genetic mutations.
- The research found that lower HVEM expression was linked to specific mutations (like FLT3-ITD and NPM1) while higher expression was associated with biallelic CEBPA mutations, and it suggested that high HVEM levels might lead to better relapse-free survival rates in AML patients.