Publications by authors named "Isabela Motta Felicio"
Repeated-Dose Toxicity of Lauric Acid and Its Preventive Effect Against Tracheal Hyper-Responsiveness in Wistar Rats with Possible Molecular Targets.
Indyra Alencar Duarte Figueiredo Alissa Maria de Oliveira Martins Alexya Mikelle Teixeira Cavalcanti Jayne Muniz Fernandes Ludmila Emilly da Silva Gomes
Pharmaceuticals (Basel)
February 2025
Background/objectives: Lauric acid (LA), a medium-chain fatty acid, is a promising drug for asthma treatment. This study evaluated the toxicity of repeated doses and the effect of LA on pulmonary ventilation and tracheal reactivity in asthmatic Wistar rats and identified possible molecular targets of LA action .
Methods: The rats were divided into control (CG) and LA-treated groups at 100 mg/kg (AL100G) for toxicity analysis.