Publications by authors named "Isabela Madeira de Castro"

Tuberculosis (TB) remains an impactful infectious disease, leading to millions of deaths every year. causes the formation of granulomas, which will determine, through the host-pathogen relationship, if the infection will remain latent or evolve into active disease. Early TB diagnosis is life-saving, especially among immunocompromised individuals, and leads to proper treatment, preventing transmission.

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is regarded as an opportunistic pathogen, causing diseases ranging from superficial infections to life-threatening disseminated infections. The ability of this yeast to form biofilms and develop resistance to antifungals represents a significant therapeutic challenge. Herein, the effect of geraniol (GER), alone and combined with fluconazole (FLZ), was evaluated in the planktonic and sessile cells of azole-resistant .

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Article Synopsis
  • - This study developed a new multiplex real-time PCR assay, called M-m-qPCR, that can quickly identify multiple viral agents causing respiratory infections, including SARS-CoV-2 and Influenza A.
  • - The assay demonstrated high accuracy with 100% specificity and the ability to detect as few as 10 viral copies, validated through tests on clinical samples and spiked nasal fluid.
  • - When tested on 811 nasopharyngeal swabs, 13.4% were positive for SARS-CoV-2 and 1.1% for Influenza A, showing results that matched perfectly with a commercial testing kit.
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Wounds of an acute or chronic etiology affect millions of people worldwide, with increasing prevalence every year. Microbial infections are one of the main causes that impair the wound healing process, and , a commensal member of the skin microbiota, is one of the main causative agents of wound infections. Crucially, a high proportion of these infections are caused by methicillin-resistant , which, in addition to β-lactams, has acquired resistance to almost all the antibacterial agents used to treat it, limiting therapeutic options.

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Article Synopsis
  • A persistent fungal colonizer can cause severe infections, especially in immunocompromised people, and is often resistant to standard antifungal treatments.
  • Researchers evaluated the antifungal effectiveness of metabolites from a bacterial strain (F4a) and their combination with biologically synthesized silver nanoparticles (bioAgNP) against both free-floating and biofilm forms of the fungus.
  • The study found that F4a and bioAgNP could significantly reduce fungal growth without harming mammalian cells, suggesting a promising new approach to treat fungal infections.
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