Publications by authors named "Isabela Akemi Guirao Sumida"
Transl Oncol
February 2022
Article Synopsis
- Sertraline hydrochloride, typically used as an antidepressant, shows potential as a cancer treatment due to its structural similarity to other drugs that inhibit the tumor protein TCTP, involved in cell growth.
- Recent studies indicate its ability to induce apoptosis (cell death), enhance autophagy (cell cleanup process), and act synergistically with other drugs, thereby reducing cancer cell proliferation across various tumor models.
- A mathematical model has been developed to estimate effective doses for humans, paving the way for future clinical trials of sertraline as a TCTP-inhibitor in cancer therapy.
