Publications by authors named "Isabela A P Goncalves"
Parasitology
November 2021
Article Synopsis
- Advances in diagnosing visceral leishmaniasis (VL) are hampered when testing samples from patients with both VL and HIV, highlighting the need for better antigens.
- A study utilized phage display to identify new peptides from serum samples of healthy individuals and those infected with VL or HIV, resulting in nine promising sequences.
- Three peptides (Pep2, Pep3, and Pep4) demonstrated excellent diagnostic performance with 100% sensitivity and specificity for VL and VL/HIV coinfection, potentially improving treatment monitoring as their levels decreased post-treatment.
Article Synopsis
- * Testing included a wide variety of serum samples from healthy and infected dogs, as well as human patients with multiple diseases, confirming LiHyQ had a 100% sensitivity and specificity.
- * Compared to commercial diagnostic kits, LiHyQ demonstrated better agreement and showed significant changes in antibody levels in treated patients, indicating its potential as a superior diagnostic tool.
