Corrigendum to "Rescue and characterization of the first West African Marburg virus 2021 from Guinea" [Heliyon Volume 9, Issue 9, September 2023, e19613].

[This corrects the article DOI: 10.1016/j.heliyon.

Recovery of Recombinant Marburg Virus by Reverse Genetics.

Reverse genetics systems can be used to study parts or all of the viral life cycle. Recovery systems are reverse genetics systems used for the generation of infectious recombinant viruses that can carry targeted mutations or express reporter genes. The former can help address basic research questions to better understand certain steps of viral replication, while recombinant viruses expressing reporter genes, such as luciferases or fluorescent proteins, can be used for drug screening assays.

The cellular protein phosphatase 2A is a crucial host factor for Marburg virus transcription.

Unlabelled: Little is known regarding the molecular mechanisms that highly pathogenic Marburg virus (MARV) utilizes to transcribe and replicate its genome. Previous studies assumed that dephosphorylation of the filoviral transcription factor VP30 supports transcription, while phosphorylated VP30 reduces transcription. Here, we focused on the role of the host protein phosphatase 2A (PP2A) for VP30 dephosphorylation and promotion of viral transcription.

Rescue and characterization of the first West African Marburg virus 2021 from Guinea.

Marburg virus (MARV) is a causative agent of a severe hemorrhagic fever with high fatality rates endemic in central Africa. Current outbreaks of MARV in Equatorial Guinea and Tanzania underline the relevance of MARV as a public health emergency pathogen. In 2021, the first known human MARV case was confirmed in Guinea, West Africa.