Multicriteria analysis for flood risk map development: a hierarchical method applied to Brazilian cities.

Floods have caused socio-economic and environmental damage globally and, thus, require research. Several factors influence flooding events, such as extreme rainfall, physical characteristics, and local anthropogenic factors; therefore, such factors are essential for mapping flood risk areas and enabling measures that mitigate the damage they cause. This study aimed to map and analyze regions susceptible to flood risk in three different study areas belonging to the same Atlantic Forest biome, in which flood disasters are recurrent.

Reducing Dietary Acrylamide Exposure from Wheat Products through Crop Management and Imaging.

The nutritional safety of wheat-based food products is compromised by the presence of the processing contaminant acrylamide. Reduction of the key acrylamide precursor, free (soluble, non-protein) asparagine, in wheat grain can be achieved through crop management strategies, but such strategies have not been fully developed. We ran two field trials with 12 soft (biscuit) wheat varieties and different nitrogen, sulfur, potassium, and phosphorus fertilizer combinations.

The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach.

The aim of this study was to characterize the oral discourse of CBS patients and to verify whether measures obtained during a semi-spontaneous speech production could differentiate CBS patients from controls. A second goal was to compare the performance of patients with CBS probably due to Alzheimer's disease (CBS-AD) pathology and CBS not related to AD (CBS-non-AD) in the same measures, based on the brain metabolic status (FDG-PET) and in the presence of amyloid deposition (amyloid-PET). Results showed that CBS patients were significantly different from controls in speech rate, lexical level, informativeness, and syntactic complexity.

Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br).

Unlabelled: Sentence-comprehension deficits have been described in patients with primary progressive aphasia (PPA). However, most instruments to address this domain in more detail and in a clinical context have not been adapted and translated into several languages, posing limitations to clinical practice and cross-language research.

Objectives: The study aimed to (1) test the applicability of the Brazilian version of the Test for Reception of Grammar (TROG2-Br) to detect morphosyntactic deficits in patients with PPA; (2) investigate the association between performance in the test and sociodemographic and clinical variables (age, years of formal education, and disease duration); (3) characterize the performance of individuals presenting with the three more common variants of PPA (non-fluent, semantic, and logopenic) and mixed PPA (PPA-Mx) and analyze whether TROG-2 may assist in the distinction of these clinical profiles.

The Correlation between Chlamydia Trachomatis and Female Infertility: A Systematic Review.

The impact of (CT) infection on female's fertility is not completely established yet, since the level of evidence associating these factors is still weak. Hence, the goal of the present review is to contribute to a better elucidation of this matter. The electronic database chosen was the Medline/PubMed, with the last survey on May 11, 2021.

Analysis of indicators of surface water pollution in Atlantic Forest preservation areas.

Managing water resources in regions with scarce data, like most developing countries, is still one of the major challenges around the world. Analysis of water quality parameters can provide important information for understanding the current status of water resources and their surroundings, including the changes that have occurred over time. This study aims to evaluate the influence of preservation areas on surface water quality in the Atlantic Forest biome.

The time of concentration application in studies around the world: a review.

The time of concentration (Tc) is the main hydrological parameter used to characterize the response of a given Hydrological Response Unit (HRU) to a precipitation event. Because of its importance, the determining Tc is an integral step in several studies involving runoff. Thus, this work presents an unprecedented review of the application of Tc in different lines of research involving water resources around the world.

Multivariate analysis of factors influencing the peak flow and runoff volume in the Cerrado and Atlantic Forest biomes in Brazil.

This study evaluates the influence of physiographic characteristics on the peak flow to runoff volume ratio in watersheds belonging to the Cerrado and Atlantic Forest biomes, in the Center-South region of Brazil. Specifically, the peak flow and runoff volume values obtained in the outlet section are related to the physiographic characteristics of the watersheds. Using a geographic information system tool, 13 watersheds are delimited, and 38 variables are selected from each watershed.

Reduced free asparagine in wheat grain resulting from a natural deletion of TaASN-B2: investigating and exploiting diversity in the asparagine synthetase gene family to improve wheat quality.

Background: Understanding the determinants of free asparagine concentration in wheat grain is necessary to reduce levels of the processing contaminant acrylamide in baked and toasted wheat products. Although crop management strategies can help reduce asparagine concentrations, breeders have limited options to select for genetic variation underlying this trait. Asparagine synthetase enzymes catalyse a critical step in asparagine biosynthesis in plants and, in wheat, are encoded by five homeologous gene triads that exhibit distinct expression profiles.

Language in corticobasal syndrome: a systematic review.

Unlabelled: Language is commonly impacted in corticobasal syndrome (CBS). However, the profile and type of language assessment in CBS are poorly studied.

Objective: To identify language impairments in CBS.

Structural and functional impact of clinically relevant E1α variants causing pyruvate dehydrogenase complex deficiency.

Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-coenzyme A, hinging glycolysis and the tricarboxylic acid cycle. PDC deficiency, an inborn error of metabolism, has a broad phenotypic spectrum. Symptoms range from fatal lactic acidosis or progressive neuromuscular impairment in the neonatal period, to chronic neurodegeneration.

Choosing an appropriate water quality model-a review.

Water quality models are quite complex to use even for scientists, requiring knowledge in different areas such as biology, chemistry, physics, and engineering. Hence, the use of these models by a non-specialist is quite complicated, demanding considerable time and research, particularly to choose which model is the most appropriate for a given situation. In this study, a comparative guide is suggested, which can help users select the appropriate water quality model for certain systems and variables.

FDG-PET Patterns Predict Amyloid Deposition and Clinical Profile in Corticobasal Syndrome.

Background: Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome related to multiple underlying pathologies.

Objective: To investigate if individual brain [ F]fluorodeoxyglucose-positron emission tomography (FDG-PET) patterns could distinguish CBS due to Alzheimer's disease (AD) from other pathologies based on [ C]Pittsburgh Compound-B (PIB)-PET.

Methods: Forty-five patients with probable CBS were prospectively evaluated regarding cognitive and movement disorders profile.

Treatment of agrammatism in oral and written production in patients with Broca's aphasia The use of implicit and explicit learning.

Unlabelled: Several approaches to the rehabilitation of agrammatism use implicit and explicit learning methods.

Objective: To verify the effect of adapted Mapping Therapy and ORLA methods (explicit versus implicit learning) on the oral and written production in spontaneous language among agrammatic patients with Broca's aphasia.

Methods: Six individuals were submitted to Mapping Therapy and ORLA (Oral Reading for Language in Aphasia) treatments.

Applicability of water quality models around the world-a review.

Water quality models are important tools used in the management of water resources. The models are usually developed for specific regions, with particular climates and physical characteristics. Thus, applying these models in regions other than those they were designed for can generate large simulation errors.

Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants.

Background: Cellular cobalamin defects are a locus and allelic heterogeneous disorder. The gold standard for coming to genetic diagnoses of cobalamin defects has for some time been gene-by-gene Sanger sequencing of individual DNA fragments. Enzymatic and cellular methods are employed before such sequencing to help in the selection of the gene defects to be sought, but this is time-consuming and laborious.

Ataxia Telangiectasia in Siblings: Oral Motor and Swallowing Characterization.

BACKGROUND The body of literature on oral motor and swallowing disorders in patients with ataxia telangiectasia (AT) is limited. CASE REPORT The purpose of this study was to characterize oral motor and swallowing disorders in two siblings with AT, based on oral motor and swallowing assessments. Specific procedures were applied for oral motor and swallowing assessments and both patients underwent videofluoroscopy (VFS).

Development and Validation of a Novel Questionnaire for Adherence with Topical Treatments in Psoriasis (QATOP).

Background: Self-report measures are the most used methodologies for the evaluation of adherence to psoriasis topical treatment, although currently there is no standard questionnaire for this purpose.

Objective: The present study aimed at developing a novel questionnaire (Questionnaire for Adherence to TOPical treatment [QATOP]) for the assessment of adherence to topical treatment in psoriasis.

Methods: A questionnaire containing nine items organized into two parts (part 1: current patient treatment; part 2: adherence to treatment, amount used, and treatment-associated variables) was developed, supported by a systematic literature review, qualitative patient focus interviews, and expert-group input.

Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency.

Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine. Patients can present to many different specialists and diagnosis is often delayed. Severely affected patients usually present in childhood with ectopia lentis, learning difficulties and skeletal abnormalities.

Arginine Functionally Improves Clinically Relevant Human Galactose-1-Phosphate Uridylyltransferase (GALT) Variants Expressed in a Prokaryotic Model.

Classic galactosemia is a rare genetic disease of the galactose metabolism, resulting from deficient activity of galactose-1-phosphate uridylyltransferase (GALT). The current standard of care is lifelong dietary restriction of galactose, which however fails to prevent the development of long-term complications. Structural-functional studies demonstrated that the most prevalent GALT mutations give rise to proteins with increased propensity to aggregate in solution.

Insights into the regulatory domain of cystathionine Beta-synthase: characterization of six variant proteins.

Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine. CBS is allosterically activated by S-adenosylmethionine (SAM), which binds to its C-terminal regulatory domain. Mutations in this domain lead to variants with high residual activity but lacking SAM activation.

Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.

S-adenosylhomocysteine (SAH) is a negative regulator of most methyltransferases and the precursor for the cardiovascular risk factor homocysteine. We have previously identified a link between the homocysteine-induced suppression of the selenoprotein glutathione peroxidase 1 (GPx-1) and endothelial dysfunction. Here we demonstrate a specific mechanism by which hypomethylation, promoted by the accumulation of the homocysteine precursor SAH, suppresses GPx-1 expression and leads to inflammatory activation of endothelial cells.