Publications by authors named "Isabel Vidal-Cobo"
Article Synopsis
- - Multiple sclerosis (MS) is an intricate disease that damages the central nervous system, and understanding its genetic basis is crucial for finding potential therapies after the advances in genome-wide association studies (GWAS).
- - Researchers identified a specific genetic variant, rs7740107, linked to MS risk at the L3MBTL3 locus by studying a group of MS patients and healthy controls, discovering it influences the expression of related genes.
- - The variant rs7740107 leads to the production of a novel short transcript that generates truncated proteins, potentially disrupting crucial interactions with other proteins that regulate the Notch signaling pathway, further influencing MS pathology.
Article Synopsis
- Trypanosomes have protein-coding genes arranged in polycistronic transcription units (PTUs), but how RNA polymerase II (Pol II) starts transcription of these units is not clear.
- Recent findings reveal core promoters between divergent PTUs, with a significant 75-bp promoter identified that effectively drives transcription and contains active motifs.
- Unlike previous beliefs of unregulated transcription, evidence shows that specific DNA sequences act as promoters, indicating that transcription initiation in Trypanosoma brucei relies on both chromatin modifications and sequence-specific regulation, akin to mechanisms in other eukaryotes.
SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The presence of a highly SUMOylated focus associated with the nuclear body, where the VSG gene is transcribed, further suggests an important role of SUMOylation in regulating VSG expression. Here, we show that SNF2PH, a SUMOylated plant homeodomain (PH)-transcription factor, is upregulated in the bloodstream form of the parasite and enriched at the active VSG telomere.
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