Publications by authors named "Isabel Sarmiento"

Background: Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subtype of pediatric leukemia with high risk factors and poor outcome. There are few reports of its prevalence in Latin America.

Aim: This study evaluated the frequency and clinical and biological characteristics of Ph-like ALL in a pediatric cancer center in Colombia.

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Background: In Colombia, hemophilia is considered a high-cost disease, and hemophilia A with high-titer inhibitors may be responsible for a significant economic pressure on the Colombian health system.

Objectives: To estimate the direct cost of care for patients with hemophilia A with high-titer inhibitors in Colombia, from the perspective of the health system.

Methods: A cost-of-illness study was carried out using standard case methodology, which was designed based on literature review and validation by expert consensus.

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Introduction: Between 60 and 80% of patients with B-cell acute lymphoblastic leukemia show genetic abnormalities which influence the prognosis of the disease and the biology of the tumor.

Objective: To analyze different genetic abnormalities in acute B lymphoblastic leukemia in children, its relationship with the immunophenotype and the proliferative rate compared with normal B cell precursors.

Materials And Methods: We assessed immunophenotype, DNA content and proliferative rate in 44 samples by flow cytometry, and translocations t(9;22), t(12;21), t(4;11), and t(1;19) by RT-PCR.

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Article Synopsis
  • The study investigated how shamans and suburban residents in Quito understand genetic terminology.
  • Both groups showed limited knowledge of genetics, mainly due to low educational levels, resulting in a lack of understanding about the subject.
  • There is a reliance on shamanic practices for medical issues, though severe cases may prompt the use of scientific medicine, highlighting the need for community programs that promote education about genetics.
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