Publications by authors named "Isabel Randazzo"
Article Synopsis
- * In this study, preterm fetal lambs were subjected to reduced oxygen levels using the EXTEND model, resulting in noticeable growth restrictions and changes in lung structure compared to those with normal oxygen levels.
- * Key findings included fewer blood vessels, increased muscularization in peripheral vessels, enlarged airspaces, and a drop in specific lung cell types and proteins crucial for lung function, indicating that fetal hypoxia mainly affects airway and surfactant production development.
Importance: Neurodevelopmental outcomes for children with congenital heart defects (CHD) have improved minimally over the past 20 years.
Objectives: To assess the feasibility and tolerability of maternal progesterone therapy as well as the magnitude of the effect on neurodevelopment for fetuses with CHD.
Design, Setting, And Participants: This double-blinded individually randomized parallel-group clinical trial of vaginal natural progesterone therapy vs placebo in participants carrying fetuses with CHD was conducted between July 2014 and November 2021 at a quaternary care children's hospital.
Background: Children undergoing complex cardiac surgery are exposed to substantial cumulative doses of sedative medications and volatile anesthetics and are more frequently anesthetized with ketamine, compared with healthy children. This study hypothesized that greater exposure to sedation and anesthesia in this population is associated with lower neurodevelopmental scores at 18 months of age.
Methods: A secondary analysis was conducted of infants with congenital heart disease who participated in a prospective observational study of environmental exposures and neurodevelopmental outcomes to assess the impact of cumulative volatile anesthetic agents and sedative medications.