Publications by authors named "Isabel Pennington"

Article Synopsis
  • - Recent studies link BACE1 activity, along with APP and Aβ, to cancer development, highlighting BACE1's potential as a target for prostate cancer (PCa) treatment.
  • - The study used various techniques to confirm BACE1 expression in human PCa tissues and cell lines and showed that BACE1 activity leads to the production of Aβ1-42, which was also detected in both tissue samples and through imaging methods.
  • - Inhibition of BACE1 with MK-8931 significantly reduced PCa cell growth in laboratory models and inhibited tumor growth in mice, suggesting BACE1 has potential as a novel therapeutic target for advanced PCa.
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