Publications by authors named "Isabel Pavon"
Context: Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness of about 50%, and subsequent drugs are indicated through clinical judgment. Some biomarkers can predict fgSRLs response.
Objective: Here we report the results of the ACROFAST study, a clinical trial in which a protocol based on predictive biomarkers of fgSRLs was evaluated.
Background: Little is known about the relationship between signal intensity patterns on T2-weighted magnetic resonance imaging (MRI) in non-functioning pituitary adenomas (NFPAs).
Objective: In this study, the clinical, hormonal, histological features, and therapeutic responses were evaluated according to the T2 signal intensity in NFPAs.
Methods: This retrospective and multicenter study included a group of 166 NFPA patients (93 men, 56%, mean age 58.
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly.
Front Endocrinol (Lausanne)
December 2023
Article Synopsis
- A short version of the acute octreotide test (sAOT) was re-evaluated to predict responses to somatostatin receptor ligands (SRLs) in acromegaly patients, utilizing ultra-sensitive growth hormone (GH) assays.
- In a study of 47 patients, the results showed that 30 were responders and 17 were non-responders, with specific GH levels serving as predictive cutoffs for treatment responses.
- The study found that patients with E-cadherin-positive tumors had lower GH levels and higher somatostatin receptor 2 (SSTR2) scores, indicating that sAOT can aid in clinical treatment decisions based on tumor characteristics.
Background: In recent years, dopamine agonists (DAs) have become an attractive therapeutic option to prevent both tumor growth and post-surgical tumor remnant growth in clinically non-functioning pituitary adenoma (NFPA).
Aim: To analyze our experience on the effect of cabergoline (CAB) on tumor remnant after initial surgery in NFPA patients.
Patients And Methods: A retrospective and multicenter study of NFPA patients with tumor remnant after surgery treated with CAB was performed.
Objective: IGF1 and IGFBP3 gene polymorphisms have been recently described. However, their potential role in the setting of acromegaly and its outcome is unknown. In this study, we analyze these polymorphisms in patients with acromegaly and investigate their association with clinical presentation and response to treatments.
View Article and Find Full Text PDFBackground And Objectives: Osteogenesis imperfecta is a rare disease with abnormal synthesis of type 1 collagen that affects diverse extra-skeletal tissues. Aortic root dilatation and valvular dysfunction have been described. Our purpose was to evaluate the prevalence of cardiac abnormalities in patients with osteogenesis imperfecta in comparison with an age and sex-matched control group of healthy people.
View Article and Find Full Text PDFObjective: The mechanisms underlying the relationship between the vascular complications of diabetes and the glycaemic control are not well understood. We tested whether glycaemic control influences the functioning of the nitric oxide system in type 1 diabetic patients and the role for oxidative stress.
Methods: The changes in the forearm blood flow after the infusion in the brachial artery of NG-monomethyl-l-arginine, methacholine, methacholine plus superoxide dismutase, and nitroprusside were evaluated using strain gauge plethysmography in 14 healthy subjects and 24 patients with type 1 diabetes (12 with HbA(1c) < 7.