The heterogeneous regional effect of mobility on Coronavirus spread.

The Coronavirus (COVID-19) pandemic struck global society in 2020. The pandemic required the adoption of public policies to control spread of the virus, underlining the mobility restrictions. Several studies show that these measures have been effective.

Peptide-Based Nanoparticles to Rapidly and Efficiently "Wrap 'n Roll" siRNA into Cells.

Delivery of small interfering RNA (siRNA) as a therapeutic tool is limited due to critical obstacles such as the cellular barrier, the negative charges of the siRNA molecule, and its instability in serum. Several siRNA delivery systems have been constructed using cell-penetrating peptides (CPPs) since the CPPs have shown a high potential for oligonucleotide delivery into the cells, especially by forming nanoparticles. In this study, we have developed a new family of short (15mer or 16mer) tryptophan-(W) and arginine-(R) rich Amphipathic Peptides (WRAP) able to form stable nanoparticles and to enroll siRNA molecules into cells.

Fertility and Economic Development: Quantile Regression Evidence on the Inverse J-shaped Pattern.

This paper analyses empirically the relationship between economic development and fertility. Through a new sample selection and quantile regression, it investigates whether there is an inverse J-shaped pattern between these two variables, and, if so, whether it depends on development and fertility levels. Our results confirm that the inverse J-shaped pattern exists, but only when a certain level of economic development is attained.