Counteracts Rotenone Effects on Spreading Depression in the Rat Brain and Protects Against Rotenone Cytotoxicity Toward Rat Glioma C6 Cells .

Astrocytes can protect neurons against oxidative stress and excitability-dependent disorders, such as epilepsy. has been used as anticonvulsant and can exert an antioxidant effect, which may underlie its opposing action against the toxic effects of the pesticide rotenone. We investigated the rotenone interaction in the cortical spreading depression (CSD), a phenomenon that depends upon brain excitability (.