Optic disc morphology in premature infants.

Background: To date, little is known about the morphology of optic discs in premature infants. However, optic disc morphology and optic nerve development are two factors that potentially influence visual function in infants. Thus we analysed the morphology of the optic disc and its correlation with gestational age and birth weight.

Diurnal Intraocular Pressure Profiles in Chronic Open-Angle Glaucoma.

Purpose: To evaluate day-and-night intraocular pressure (IOP) profiles in normal and glaucomatous eyes.

Design: Hospital-based clinical observational study.

Methods: The study included 3561 day-and-night profiles of IOP measurements performed by Goldmann applanation tonometry on 1408 eyes of 720 normal Caucasian subjects or chronic open-angle glaucoma patients.

Circadian intraocular pressure profiles in chronic open angle glaucomas.

Purpose: To evaluate circadian intraocular pressure (IOP) profiles in eyes with different types of chronic open-angle glaucoma (COAG) and normal eyes.

Methods: This study included 3,561 circadian IOP profiles obtained from 1,408 eyes of 720 Caucasian individuals including glaucoma patients under topical treatment (1,072 eyes) and normal subjects (336 eyes). IOP profiles were obtained by Goldmann applanation tonometry and included measurements at 7 am, noon, 5 pm, 9 pm, and midnight.

Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage.

Purpose: To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression.

Methods: The hospital-based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open-angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated, and corneal pachymetry and achromatic perimetry were performed.

Central corneal thickness and development of glaucomatous optic disk hemorrhages.

Purpose: To evaluate whether central corneal thickness influences the development of optic disk hemorrhages in chronic open-angle glaucoma.

Design: Prospective observational clinical study.

Methods: The study included 390 eyes of 223 white subjects with chronic open-angle glaucoma observed during a mean follow-up time of 61.

Single intraocular pressure measurements and diurnal intraocular pressure profiles.

Purpose: To evaluate the probability of a single intraocular pressure measurement to be the highest measurement within a diurnal intraocular pressure profile.

Design: Hospital-based clinical, observational study.

Methods: The study included 3,025 day-and-night intraocular pressure profiles measured on 1,072 eyes of 547 Caucasian glaucoma patients or glaucoma suspects.

Bilateral optic neuropathy and unilateral tonic pupil associated with acute human herpesvirus 6 infection: a case report.

Background: Human herpesvirus 6 (HHV-6), a widespread virus and causative agent of exanthema subitum in children, has been associated with a number of neurologic disorders including cranial nerve palsies, seizures, encephalitis, meningitis, and multiple sclerosis.

Patient: A 31-year-old man presented with bilateral optic neuropathy, disc edema, and unilateral tonic pupil, which were found to be associated with acute HHV-6 infection. The patient had been suffering from juvenile diabetes for 5 years.