Publications by authors named "Isabel M Larus"
Autophagy mediates the degradation of intracellular macromolecules and organelles within lysosomes. There are three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy. Heat shock protein 70.
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- Secreted modular calcium-binding proteins (SMOCs) are evolutionary conserved proteins present in various organisms, including humans and worms, characterized by their calcium-binding and thyroglobulin domains.
- In C. elegans, the sole SMOC protein (CeSMOC-1) was shown to bind to the proteoglycan LON-2/glypican and the BMP homolog DBL-1, suggesting a complex interaction that influences BMP signaling pathways.
- The study revealed that CeSMOC-1 has dual regulatory roles: it negatively impacts BMP signaling through LON-2 and positively influences it via DBL-1, contributing to our understanding of SMOC protein functions in cellular signaling.