Publications by authors named "Isabel M Kloer"
Objective: The objective of this study was to describe the rationale and design of two multinational phase 3 clinical trials of survodutide, an investigational glucagon and glucagon-like peptide-1 receptor dual agonist for the treatment of obesity with or without type 2 diabetes (T2D; SYNCHRONIZE-1 and -2).
Methods: In these ongoing double-blind trials, participants were randomized to once-weekly subcutaneous injections of survodutide or placebo added to lifestyle modification. Survodutide doses are uptitrated to 3.
Article Synopsis
- The combined use of tiotropium and olodaterol was shown to be safe and effective for treating COPD, including in patients with varying degrees of renal impairment, based on findings from the TONADO studies.
- The studies involved 3,041 COPD patients, with many having pre-existing conditions like cardiac issues and hypertension, yet renal impairment did not significantly impact the occurrence of adverse events among different treatments.
- Overall, the research indicates that the combination treatment does not pose additional risks related to renal function compared to the individual medications.