Publications by authors named "Isabel Lai"
: Cardiorespiratory fitness positively correlates with longevity and immune health. Regular exercise may provide health benefits by reducing systemic inflammation. In chronic disease conditions, such as chronic heart failure and chronic fatigue syndrome, mechanistic links have been postulated between inflammation, muscle weakness, frailty, catabolic/anabolic imbalance, and aberrant chronic activation of immunity with monocyte upregulation.
View Article and Find Full Text PDFPurpose: To determine the relationship of intraocular pressure (IOP) control with subsequent retinal nerve fiber layer (RNFL) thinning in patients with primary angle closure disease (PACD).
Design: Prospective cohort study.
Methods: The study monitored 517 treated PACD eyes from 280 Chinese patients at least 24 months.
Purpose: To compare combined phacoemulsification plus endoscopic cyclophotocoagulation (ECP) versus phacoemulsification alone in primary angle-closure glaucoma (PACG) with coexisting cataract.
Design: Prospective randomized controlled clinical trial-a pilot study.
Participants: Forty-eight PACG eyes of 48 patients with coexisting cataract.
Purpose: To investigate the features of the small-to-medium (choriocapillaris and Sattler's layer) and large (Haller's layer) sized vessel layers of the macular choroid in normal-tension glaucoma (NTG) patients using swept-source optical coherence tomography (SS-OCT).
Methods: We conducted an observational cross-sectional study in 234 NTG eyes from 134 patients, and 203 normal eyes from 109 non-glaucomatous control subjects. We used Image J to segment the choroidal layer and then a Python script to measure the average macular choroidal thickness (MCT) and choroidal vascular index (CVI) of two vessel layers at five different locations.
Aims: To compare the intraocular pressure (IOP) lowering effect and safety profile between pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) over a 12-month follow-up.
Methods: 132 patients with POAG or OHT were consecutively enrolled and randomised (1:1) to receive PSLT (n=65) or SLT (n=67) in a single centre. IOP was measured before and then on 1 day, 1 week, 1, 3, 6, 9 and 12 months after PSLT/SLT.
Article Synopsis
- - This study investigated factors that affect long-term intraocular pressure (IOP) fluctuations in patients with primary angle closure disease (PACD), specifically focusing on demographics, ocular characteristics, and systemic health issues.
- - Data from 422 eyes of 269 Chinese patients with PACD were analyzed, finding that those with primary angle closure glaucoma (PACG) experience more significant IOP fluctuations compared to those with primary angle closure/primary angle closure suspect (PAC/PACS).
- - Key associations identified included higher fluctuation linked to older age, male sex, higher baseline IOP, and smoking in PAC/PACS eyes, while diabetes was associated with lower fluctuation, highlighting the impact of various factors on IOP stability in PACD.
Objective: To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma.
Design: Cross-sectional study.
Participants: Twenty-three eyes with PAS (detected by indentation gonioscopy) from 20 patients with angle-closure glaucoma (20 eyes had primary angle-closure glaucoma and 3 eyes had angle-closure glaucoma secondary to chronic anterior uveitis [n = 2] and Axenfeld-Rieger syndrome [n = 1]).