Publications by authors named "Isabel L Wood"
J Med Chem
September 2024
Article Synopsis
- The study focuses on optimizing inhibitors for epidermal growth factor receptor (EGFR) Exon20 insertions (Ex20Ins) using structure-based drug design (SBDD).
- A new compound was discovered that is both effective against EGFR Ex20Ins and able to cross the blood-brain barrier in preclinical tests.
- The design process involved creating a novel bicyclic structure, making strategic modifications to improve stability and enhance brain exposure by refining key molecular properties.
