Publications by authors named "Isabel Haupfear"
Rationale: Extracellular proteolytic activity plays an important role in memory formation and the preservation of cognitive function. Previous studies have shown increased levels of plasminogen activator inhibitor-1 (PAI-1) in the brain of mouse models of Alzheimer's disease (AD) and plasma of AD patients, associated with memory and cognitive decline; however, the exact function of PAI-1 in AD onset and progression is largely unclear.
Objective: In this study, we evaluated a novel PAI-1 inhibitor, TM5A15, on its ability to prevent or reverse memory deficits and decrease Aβ levels and plaque deposition in APP/PS1 mice.
Article Synopsis
- Many people with Alzheimer's disease show symptoms like apathy, which means they may not feel interested in things they used to enjoy.
- This study looked at mice, both normal and ones with a condition similar to Alzheimer's, at different ages to see how they acted and remembered things.
- The results showed that the mice with the condition started acting apathetic by 6 months old, and this behavior was linked to certain brain changes that got worse as they aged.