Manganese neurotoxic time course is not influenced by L-deprenyl systemic treatment: influence of L-deprenyl in manganese neurotoxic time course.

Unilateral microinjection of manganese into the rat substantia nigra pars compacta (SNpc) leads to the death of nigral neurons and a decrease in dopamine (DA) within the ipsilateral striatum. L-deprenyl, an irreversible inhibitor of monoamine oxidase B, appears to protect or rescue dopaminergic nigral neurons from the toxic effects of 6-hydroxydopamine (6-OHDA) and 1-methyl-4 phenyl-1, 2, 3, 6-tetrahydropiridine (MPTP). In this study we aimed to investigate whether L-deprenyl is able to influence the manganese neurotoxic time course.