Publications by authors named "Isabel Cordova-Oriz"
Article Synopsis
- The study investigates the role of long non-coding telomeric repeat-containing RNAs as potential biomarkers for idiopathic male infertility, focusing on two groups of men: those with normal sperm (normozoospermic) and those with reduced sperm quality (oligoasthenozoospermic).
- Findings reveal that oligoasthenozoospermic men not only had worse sperm quality but also produced embryos with lower inner-cell-mass quality, and they exhibited shorter telomeres and more sperm with abnormal telomeric structures compared to normozoospermic men.
- A positive correlation was noted between telomeric RNA levels and sperm motility in normozoospermic men, suggesting
Article Synopsis
- Telomeres are protective structures at the ends of chromosomes, initially described in the 1930s, which were linked to the limits of cell division and aging by Alexey M. Olovnikov in the 1970s.
- Telomere shortening affects life expectancy and is countered by telomerase, an enzyme found in cancer and stem cells, while their dynamics differ between male and female gametes.
- Short telomere lengths in ovarian cells can lead to reduced fertility and higher rates of embryo abnormalities, prompting interest in telomere lengthening strategies and the impact of lifestyle factors on fertility.
Article Synopsis
- Women experiencing ovarian failure (OF) often show short telomeres and low telomerase activity, suggesting a link between telomere health and fertility issues; using sexual steroids to reactivate telomerase might improve IVF outcomes.
- A double-blind study with patients having diminished ovarian reserve showed that those treated with Danazol for 3 months had changes in telomere dynamics, although overall telomere length remained similar.
- Treatment with Danazol improved the maturity rate of oocytes in later ovarian stimulation cycles, indicating potential benefits for IVF success, but further studies are necessary to validate these findings.
Article Synopsis
- Ovarian aging leads to infertility, with telomere attrition being a common factor in both aging and fertility issues; the study uses the SAMP8 mouse model to explore these effects at the point of reproductive senescence.
- Key findings indicate that SAMP8 females have a shorter lifespan and decreased telomere length in both blood and ovaries compared to control mice, which correlates with lower telomerase activity and expression.
- The research highlights significant differences in telomere lengths among ovarian follicles, with SAMP8 females showing reduced proportions of long telomeres in granules and follicles, impacting their overall reproductive capability.
Purpose Of Review: Women's fertility decay starts at the mid 30 s. However, the current delay of childbearing leads to ovarian aging and the need of assisted reproduction technologies (ART). Telomere biology is one of the main pathways involved in organismal aging.
View Article and Find Full Text PDFResearch Question: How do age and normo- or oligoasthenozoospermia affect telomere length dynamics in spermatozoa and blood?
Design: Sperm and blood samples were collected from a cohort of 37 men aged 25 and under and 40 men aged 40 and over, with either normozoospermia (NZ) or oligoasthenozoospermia (OAZ). Telomere length was evaluated using quantitative fluorescence in-situ hybridization. Telomerase mRNA (TERC and TERT) and shelterin (TRF1) gene expression were analysed using quantitative real-time polymerase chain reaction.
Successful reproduction is very important for individuals and for society. Currently, the human health span and lifespan are the object of intense and productive investigation with great achievements, compared to the last century. However, reproduction span does not progress concomitantly with lifespan.
View Article and Find Full Text PDFThe trend in our society to delay procreation increases the difficulty to conceive spontaneously. Thus, there is a growing need to use assisted reproduction technologies (ART) to form a family. With advanced maternal age, ovaries not only produce a lower number of oocytes after ovarian stimulation but also a lower quality-mainly aneuploidies-requiring further complex analysis to avoid complications during implantation and pregnancy.
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