Publications by authors named "Isabel Coelho"
Article Synopsis
- Urinary tract infections (UTIs) and urinary tract colonizations (UTCs) are prevalent in patients with spinal cord injury (SCI), prompting a study to analyze the microbial profiles and antibiotic resistance found in urine cultures of these patients.
- The study reviewed 235 urine culture results from 29 SCI patients over eight years, finding that UTIs occurred in 57% of samples while UTCs were identified in 43%.
- Most identified bacteria were resistant to fluoroquinolones but showed low resistance to cephalosporins and very low resistance to nitrofurantoin, highlighting the importance of tailoring antibiotic treatments based on specific culture results.
Article Synopsis
- DRESS is a severe and rare drug reaction often linked to certain medications like antibiotics and anticonvulsants, typically presenting with symptoms like rash, fever, and organ involvement.
- A 17-year-old girl experienced multiple symptoms after starting minocycline, leading to a misdiagnosis of serum sickness before correctly identifying DRESS.
- The case underscores the complexities of diagnosing and treating DRESS, emphasizing the need for careful monitoring and a comprehensive patient evaluation.
The reinforcement of acrylic denture base remains problematic. Acrylic prosthesis fractures are commonly observed in prosthodontic practice and have not been reliably resolved. This study compared the resistance to masticatory force of acrylic bases of removable complete conventional prosthesis in 3D upper models.
View Article and Find Full Text PDFNR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study.
Am J Med Genet B Neuropsychiatr Genet
July 2004
The present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human brain development and regulation.
View Article and Find Full Text PDFGenetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT).
View Article and Find Full Text PDFMultiple sclerosis (MS) is a demyelinating disease that affects about one in 500 young Europeans. In order to test the previously proposed influence of the APOE and SCA2 loci on susceptibility to MS, we studied these loci in 243 Portuguese patients and 192 healthy controls and both parents of 92 patients. We did not detect any significant difference when APOE and SCA2 allele frequencies of cases and controls were compared, or when we compared cases with different forms of the disease.
View Article and Find Full Text PDFBackground: Alterations in dopaminergic and serotonergic systems have been implicated in the pathophysiology of schizophrenia for many years. This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Da, 1Db, and 2A in the etiology of schizophrenia.
Methods: We examined 33 multiplex schizophrenic families from Portugal.