Publications by authors named "Isabel Chavez-Uribe"
Chem Res Toxicol
June 2014
Article Synopsis
- The scorpion toxin tamapin is the most effective blocker of KCa2.2 channels, with this study examining its creation, structure, and cancer cell toxicity.
- Researchers tested tamapin and five mutated versions on Jurkat T and breast cancer cells, finding that tamapin and its variants caused cell death in a dose- and time-dependent manner.
- Structural analysis showed that tamapin maintains its shape despite mutations, while changes in toxicity suggest the importance of specific amino acids in interacting with KCa2.2 channels to induce cell death.
