Cocaine Increases Sensorimotor Gating and is Related to Psychopathy.

Objective: Prepulse inhibition regulates sensorimotor gating and is a marker of vulnerability to certain disorders. We compared prepulse inhibition, psychopathy, and sensitivity to punishment and reward in patients with cocaine-related disorder without psychiatric comorbidities and a control group.

Methods: This was an observational study of a sample of 22 male cases with cocaine-related disorder and 22 healthy male controls.