[HIV and dentistry. Part 6. Mouth defects in HIV infections: guidelines for referral].

As for any oral lesion that cannot be properly diagnosed by the dentist, referral to the specialist is indicated for lesions that might be associated with or indicative of an underlying HIV infection. In most instances, there is no need to discuss the subject of HIV infection in the dental office. In the letter of referral the same information should be given as has been provided to the patient.

[HIV and dentistry. Part 5. Practice hygiene].

When complying a good standard hygiene protocol in the dental office the risk of cross-infection of whatever type of microorganism, including the hepatitis-B-virus and HIV, is almost eliminated.

[HIV and dentistry. Part 4. Oral deviations in HIV infections: present classification and diagnostic criteria].

In the present classification of oral lesions associated with HIV infection a distinction is made between presumptive and definitive diagnostic criteria. The former relate to the initial clinical appearance of the lesion and the latter are often the result of special investigations. Candidiasis, hairy leukoplakia, specific forms of periodontal disease, Kaposi's sarcoma and non-Hodgkin's lymphoma are strongly associated with HIV infection.

Primary malignant melanoma of the oral cavity: a review of eight cases.

A review of oral malignant melanoma and data of eight patients are presented. The dismal prognosis of the condition is probably mainly due to its long, 'silent' course. In one-third of cases melanosis precedes the tumour--it is this condition that should alert clinicians.

[HIV and dentistry. Part 3. HIV infection: pathogenesis, epidemiology, definitions and classification].

The acquired immunodeficiency syndrome (AIDS) is caused by a retrovirus, the human immunodeficiency virus (HIV), that selectively deteriorates cell-mediated immunity. Consequently fatal opportunistic infections and/or malignancies occur. In this paper the pathogenesis and the epidemiology of HIV infection are described.

[HIV and dentistry. Part 2. Needlestick injury].

The risk for dentists to acquire HIV infection at work is low but not neglectable. Needlestick injuries are among the most hazardous events in this respect. Prevention of these injuries will considerably reduce the risk of occupational HIV infection in dentistry.

Risk of multiple primary tumors following oral squamous-cell carcinoma.

The follow-up of 727 patients with squamous-cell carcinoma (SCC) of the lip and oral cavity has been used for the risk analysis of multiple primary tumors (MPTs) following SCC of the lip and oral cavity. Age-, gender- and site-specific cancer-incidence rates from the general population have been applied to the appropriate persons-years of follow-up of patients with SCC of the lip and oral cavity. The study indicates that patients with a primary SCC of the lip and oral cavity have, compared with the general population, a significantly elevated risk of developing an additional cancer of the oral cavity and/or pharynx, the risk being 74.

[HIV and dentistry. Part 1: Disclosure of HIV-seropositivity to the dentist].

For a number of reasons it is recommended to disclose one's HIV-seropositivity to the dentist. This information will enable the dentist to take extra precautions during treatment. Furthermore, extra measures may be taken with regard to prevention or early treatment of dental and oral diseases, e.

Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor.

Background: Biologic aggressiveness of head and neck carcinoma is reflected in its capability to metastasize to regional lymph nodes and its propensity to recur after treatment.

Methods: The authors report on 244 patients treated at the Department of Otolaryngology-Head and Neck Surgery of the Free University Hospital, Amsterdam, The Netherlands, with excision of primary tumor with incontinuity neck dissection with or without postoperative radiation therapy between January 1973 and July 1986. All patients had surgical margins free of tumor.

Primary extranodal non-Hodgkin lymphoma of the oral cavity. An analysis of 34 cases.

34 patients with primary extranodal non-Hodgkin lymphoma (PE-NHL) of the oral cavity have been studied with reference to age, sex, clinical symptoms, location of primary tumour, histological subtype, grade of malignancy according to the Working Formulation, stage of disease, treatment and follow-up. The clinicopathological features of these oral PE-NHL correspond with those of PE-NHL in general. Survival was influenced by stage of disease and grade of malignancy.

Regional odontodysplasia: report of three cases.

Regional odontodysplasia is a developmental anomaly of dental tissues with characteristic clinical, radiographic, and histologic appearances. It most commonly affects the maxillary anterior teeth of both the primary and permanent dentition, and occurs in females twice as often as in males. The pathogenesis is unknown.

Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma.

The aim of the present study was to evaluate the possible relationship between tobacco smoking and alcohol drinking and the anatomical sites of squamous cell carcinoma (SCC) of the lip and oral cavity. For this purpose, a case-case study has been performed in 690 patients. The study was focused on the relative risk (RR) or developing SCC at various (sub)sites, for smokers and drinkers of alcohol (divided into moderate and heavy users) relative to non-smokers and non-drinkers.

Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas.

This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.

Catheter for percutaneous thrombectomy: first clinical experience.

The authors evaluated a double-lumen thrombectomy catheter that functions by way of the Venturi effect in seven consecutive patients with thrombus in the superficial femoral artery. The estimated age of the thrombotic material was between 3 days and 9 weeks. Thrombectomy was successful in all patients, and mean time required was less than 20 minutes.

Lichen sclerosus et atrophicus involving the oral mucosa: report of two cases.

Lichen sclerosus et atrophicus (LSA) is a relatively rare dermatosis of unknown etiology. The disease is clinically characterized by white, macular lesions on the skin, and is usually associated with an atrophic condition affecting the vulva and peri-anal skin. Involvement of the oral mucosa with or without concurrent genital or skin lesions has been reported only occasionally in the literature.

Squamous cell carcinoma of the lip and oral cavity in The Netherlands; an epidemiological study of 740 patients.

The epidemiological data of 740 patients with primary squamous cell carcinoma (SCC) of the lips or oral cavity is reported. The mean age was 63 years. The mean onset of oral cancer in women was 7 years later than in men.

Monitoring occupational exposure to ethylene oxide by the determination of hemoglobin adducts.

In a study on workers in a chemical plant where ethylene oxide (EtO) is manufactured and partly used for ethylene glycol production, exposure to EtO was monitored during annual periodic health assessments in January 1988, December 1988, and March 1990 by the determination of the level of 2-hydroxyethylvaline (HOEtVal) in hemoglobin. The HOEtVal levels in workers corresponded with the potential EtO exposures. The highest level was found in December 1988, in blood samples collected 1-2 months after a shut-down, maintenance, and start-up program.