Publications by authors named "Isaac T Sluder"
Article Synopsis
- Cutaneous pyogenic granulomas (PGs) are benign tumors with unclear causes, but recent research indicates they may be linked to genetic changes in specific cellular pathways.
- The authors discuss three cases of spontaneous multifocal PGs that began during infancy, lacking associated vascular issues or clear causes, and show genetic mutations in the Ras/Raf/MAPK pathway.
- These PGs did not respond well to treatments like beta-blockers and mTOR inhibitors, but improved significantly with pulsed dye laser therapy; the authors suggest the term "spontaneous multifocal PGs" for this condition.
Hsp70 is a well-conserved molecular chaperone involved in the folding, stabilization, and eventual degradation of many "client" proteins. Hsp70 is regulated by a suite of co-chaperone molecules that assist in Hsp70-client interaction and stimulate the intrinsic ATPase activity of Hsp70. While previous studies have shown the anticancer target ribonucleotide reductase (RNR) is a client of Hsp70, the regulatory co-chaperones involved remain to be determined.
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