Publications by authors named "Isaac T Freichels"
Restricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or adult mice. However, their effects when initiated in aged animals are unknown. Here we investigate the consequences of consuming a diet with 67% reduction of all amino acids (low AA) or of isoleucine alone (low Ile), in male and female C57BL/6J.
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- Dietary protein plays a key role in healthy aging, with low-protein diets extending lifespan and improving healthspan in mice.
- A significant reduction in amino acids, either overall or specifically isoleucine, led to decreased body fat and better glucose tolerance without cutting calorie intake.
- Both dietary regimens also showed improvements in frailty and molecular markers of aging, suggesting potential benefits for healthy aging in older individuals.