Publications by authors named "Isaac Silvere Gade"

The phytochemical study of L. led to the isolation, through chromatographic techniques, of a new triterpenoid saponin, 3--[--rhamnopyranosyl-(1→3)-(6--acetyl---glucopyranosyl)]-22-hydroxyolean-12-ene () namely Myxaoside A, together with three known compounds, Soyasaponine I (), oleanolic acid (), and 3--acetyl-oleanolic acid (). All structures were established, based on 1 & 2D-NMR spectroscopic analysis and comparison with previous published reports.

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Background: Plants play an important role in cancer therapy. They are source of natural molecules which can induce apoptosis in cancer cells by affecting molecular mechanisms implicated in cancer progression. The MAP Kinase/ERK1/2 and PI3K/AKT signaling pathways are two classical signaling pathways implicated in cancer progression and constitute therapeutic targets against cancer.

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A phytochemical study was carried out on stem bark of F. Hoffm., a medicinal plant belonging to the Combretaceae family and used traditionally in the treatment of various ailments.

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Article Synopsis
  • A new diterpenoid called rubesanolidic acid was discovered alongside six known compounds from the roots of a particular plant using column chromatography.
  • Their structures were confirmed through various spectroscopic analyses and comparisons with prior research data.
  • The extract showed significant -amylase inhibition activity, outperforming individual compounds, with rubesanolidic acid displaying the highest inhibition among the isolated compounds, suggesting the plant has potential as a source for antidiabetic agents.
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The present work describes the isolation and anticancer activity of which is a hemi parasitic plant harvested on , the host plant. Phytochemical study afforded a new flavonoid glycoside, tapinantoside () isolated for the first time from natural source, alongside six known compounds (-). Structure of compounds were elucidated by extensive spectroscopic analyses including 1 D and 2 D NMR, mass spectrometry and by comparison with literature data.

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Background: Cancer incidence has been growing in an alarming rate worldwide and new therapeutics are needed, particularly for intractable and chemoresistant cases. We evaluated the cytotoxic effects of Combretum fragrans F. Hoffm (Combretaceae) on glioblastoma (U87MG and C6) and prostate (PC-3) cancer cell lines.

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