Publications by authors named "Isaac J Villegas"
Article Synopsis
- * The study found that iPSC-derived midbrain neurons from patients with Jordan syndrome exhibited notable differences in dopamine-related pathways and neuronal structure.
- * Researchers tested a CRISPR-based method to correct genetic mutations in neural stem cells, discovering that factors like sgRNA length and cell type affect the efficiency of RNA editing, suggesting a promising avenue for treating NDDs.
Angelman syndrome (AS) is a neurogenetic disorder caused by the loss of ubiquitin ligase E3A (UBE3A) gene expression in the brain. The UBE3A gene is paternally imprinted in brain neurons. Clinical features of AS are primarily due to the loss of maternally expressed UBE3A in the brain.
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