Publications by authors named "Isaac J Benque"
Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by pathological T cell-B cell interactions. Expansion of T follicular helper (T) and T peripheral helper (T) cells, two T cell populations that provide help to B cells, is a prominent feature of SLE. Human T and T cells characteristically produce high levels of the B cell chemoattractant CXCL13 (refs.
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- Immune checkpoint inhibitors (ICIs) are effective cancer treatments but can lead to immune-related adverse events (irAEs) affecting multiple organs, particularly in the gastrointestinal and hepatic systems.
- A review of recent literature on these toxicities emphasizes the need for gastroenterologists to identify and manage conditions like enterocolitis, hepatitis, and others, using strategies from relevant oncology guidelines.
- The management of irAEs involves assessing severity, ruling out other causes, and employing treatments such as corticosteroids and immunosuppressants, but clinical guidelines are primarily based on retrospective data.
The ocular microenvironment has evolutionarily adapted several mechanisms of immunosuppression to minimize the induction of inflammation. Neuropeptides produced by the retinal pigment epithelial cells regulate macrophage activity. Two neuropeptides, α-melanocyte-stimulating hormone (α -MSH) and neuropeptide Y (NPY), are constitutively expressed by the retinal pigment epithelial cells.
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