Publications by authors named "Isaac H Chen"
Article Synopsis
- Glioblastoma (GBM) is a lethal brain cancer that infiltrates the brain and can form synapses with neurons, contributing to its progression.
- This study used a rabies virus tracing technique to show that human GBM cells transplanted into mice integrate quickly into various neuronal circuits and receive diverse synaptic inputs, including neuromodulatory signals.
- Activation of the acetylcholine receptor CHRM3 in GBM cells was found to trigger invasive behavior and increased survival, suggesting that synaptic connections play a crucial role in enhancing tumor aggressiveness.
Metastatic Meningioma of the Neck: A Case Report and Systematic Review.
ORL J Otorhinolaryngol Relat Spec
September 2022
Background: Although meningiomas are the most common central nervous system neoplasms, extracranial metastases are exceedingly rare. There are even fewer reports of metastatic meningiomas to the neck.
Methods: We described a patient with multiply recurrent orbital meningioma with metastasis to the neck found incidentally during neck exploration for composite resection and free tissue reconstruction.