Publications by authors named "Isaac B Plutzer"
Article Synopsis
- NRF2 is a special protein that helps protect cells from damage and is related to both cancer and brain diseases like Parkinson's.
- Researchers studied how NRF2 interacts with other proteins to figure out what affects its activity.
- They found that a protein called ZNF746 can stop NRF2 from working properly, which can worsen conditions like Parkinson's but can be reversed by boosting NRF2 activity.
Across species, lifespan is highly variable among individuals within a population. Even genetically identical reared in homogeneous environments are as variable in lifespan as outbred human populations. We hypothesized that persistent inter-individual differences in expression of key regulatory genes drives this lifespan variability.
View Article and Find Full Text PDFWe miniaturized standard, solid-phase C. elegans culture conditions to produce a system in which many isolated, individual C. elegans can be housed throughout their lives.
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