Therapeutic Potential of Propolis Extract in Managing Hyperinflammation and Long COVID-19: A Bioinformatics Study.

Hyperinflammation is a significant factor in long COVID, impacting over 65 million post-COVID-19 individuals globally. Herbal remedies, including propolis, show promise in reducing severity and pro-inflammatory cytokines. However, the natural pharmacological role of propolis in COVID-19 management remains underexplored.

Bioinformatics design of peptide binding to the human cardiac troponin I (cTnI) in biosensor development for myocardial infarction diagnosis.

Cardiovascular disease has reached a mortality rate of 470,000 patients each year. Myocardial infarction accounts for 49.2% of these deaths, and the cTnI protein is a crucial target in diagnosing myocardial infarction.

Evaluation of electrodeposition synthesis of gold nanodendrite on screen-printed carbon electrode for nonenzymatic ascorbic acid sensor.

Gold nanodendrite (AuND) is a type of gold nanoparticles with dendritic or branching structures that offers advantages such as large surface area and high conductivity to improve electrocatalytic performance of electrochemical sensors. AuND structures can be synthesized using electrodeposition method utilizing cysteine as growth directing agent. This method can simultaneously synthesize and integrate the gold nanostructures on the surface of the electrode.

The molecular interaction of six single-stranded DNA aptamers to cardiac troponin I revealed by docking and molecular dynamics simulation.

Cardiac troponin I (cTnI) is a cardiac biomarker for diagnosing ischemic heart disease and acute myocardial infarction. Current biochemical assays use antibodies (Abs) due to their high specificity and sensitivity. However, there are some limitations, such as the high-cost production of Abs due to complex instruments, reagents, and steps; the variability of Abs quality from batch to batch; the low stability at high temperatures; and the difficulty of chemical modification.

A comprehensive study on transparent conducting oxides in compact microbial fuel cells: Integrated spectroscopic and electrochemical analyses for monitoring biofilm growth.

Microbial fuel cells (MFCs) are an emerging technology that holds promise for renewable energy production and the mitigation of environmental challenges. This research paper introduces a single-compartment MFC reactor that utilizes transparent conducting oxides (TCOs), such as fluorine-doped tin oxide (FTO) and indium tin oxides (ITO), as the working electrodes. The effectiveness of MFCs based on FTO and ITO was evaluated by characterizing the transparent electrode and examining its performance during biofilm cultivation.

Flower like-novel nanocomposite of Mg(TiSn)Odecorated on reduced graphene oxide (rGO) with high capacitive behavior as supercapacitor electrodes.

In this study, ceramic materials of Mg(TiSn)Owere synthesized and decorated on reduced graphene oxide, forming a nanocomposite of rGO/Mg(TiSn)O(rGO/MTS001). The successful synthesis results were confirmed by XRD, UV-vis analysis, FT-IR, and SEM-EDS. The MTS001 has a flower-like morphology from scanning electron microscopy (SEM) analysis, and the nanocomposites of rGO/MTS001 showed MTS001 particles decorated on the rGO's surface.

Revealing Propolis Potential Activity on Inhibiting Estrogen Receptor and Heat Shock Protein 90 Overexpressed in Breast Cancer by Bioinformatics Approaches.

Breast cancer is the most commonly diagnosed cancer globally, with the highest incidence of breast cancer occurring in Asian countries including Indonesia. Among the types of breast cancer, the estrogen receptor (ER)-positive subtype which is prominent with estrogen receptor alpha () and heat shock protein 90 () overexpression genes becomes the most prevalent than the others, approximately 75% of all breast cancer cases. ERα and HSP90 play a role in breast cancer activities including breast tumor growth, invasion, and metastasis mechanism.

Durable nonenzymatic electrochemical sensing using silver decorated multi-walled carbon nanotubes for uric acid detection.

In this study, we demonstrate a facile, durable, and inexpensive technique of producing silver nanoparticles-decorated multi-walled carbon nanotubes (MWCNT/AgNP) on the easy-to-use screen-printed carbon electrodes (SPCE) for non-enzymatic detection of uric acid (UA) in an electrochemical sensor. The developed sensors show great durability for three months in storage, and high specificity performance for preclinical study using spiked UA in a synthetic urine sample. A simple route for this hybrid nanocomposite was proposed through an oxidation-reduction with reflux (ORR) process.

The assessment of molecular dynamics results of three-dimensional RNA aptamer structure prediction.

Aptamers are single-stranded DNA or RNA that bind to specific targets such as proteins, thus having similar characteristics to antibodies. It can be synthesized at a lower cost, with no batch-to-batch variations, and is easier to modify chemically than antibodies, thus potentially being used as therapeutic and biosensing agents. The current method for RNA aptamer identification in vitro uses the SELEX method, which is considered inefficient due to its complex process.

The revelation of glucose adsorption mechanisms on hierarchical metal-organic frameworks using a surface plasmon resonance sensor.

The gold layer on the surface plasmon resonance (SPR) sensor chip cannot detect small molecules, such as glucose without the use of specific receptors. Metal-organic frameworks (MOFs) are useful in biosensing technologies for capturing and co-localizing enzymes and receptors with the target biomolecule. In many previous studies, the properties of the MOFs were often ignored, with these studies focusing on the selection of appropriate receptors.

Immunoinformatics Study: Multi-Epitope Based Vaccine Design from SARS-CoV-2 Spike Glycoprotein.

The coronavirus disease 2019 outbreak has become a huge challenge in the human sector for the past two years. The coronavirus is capable of mutating at a higher rate than other viruses. Thus, an approach for creating an effective vaccine is still needed to induce antibodies against multiple variants with lower side effects.

CeO@NH functionalized electrodes for the rapid detection of SARS-CoV-2 spike receptor binding domain.

A detection method based on an electrochemical aptasensor has been developed as an alternative fast, portable, simple, inexpensive, and high-accuracy detection method for detecting the SARS-CoV-2 Spike Receptor Binding Domain (spike RBD). The CeO@NH functionalized Screen Printed Carbon Electrode (SPCE) was used to immobilize an aminated aptamer of spike RBD protein glutaraldehyde as a linker. The aptamer's interaction with the SARS-CoV-2 Spike RBD was measured the [Fe(CN)] redox system signal.

Development of a Single-Chain Variable Fragment of CR3022 for a Plasmonic-Based Biosensor Targeting the SARS-CoV-2 Spike Protein.

Two years after SARS-CoV-2 caused the first case of COVID-19, we are now in the "new normal" period, where people's activity has bounced back, followed by the easing of travel policy restrictions. The lesson learned is that the wide availability of accurate and rapid testing procedures is crucial to overcome possible outbreaks in the future. Therefore, many laboratories worldwide have been racing to develop a new point-of-care diagnostic test.

Simulation of Laser-Heating and Energetic Plasma Plume Expansion in Pulsed Laser Deposition of YFeO.

In the present study, numerically iterative models are employed to study two processes involved in the pulsed laser deposition of an YFeO target. The 1D conduction heat model is used to evaluate the temperature of the target irradiated by a nano-second pulse laser, taking into account the plasma shielding effect. Further, the gas dynamics model is employed to simulate the kinetic of plasma plume expansion.

Facile and controllable synthesis of monodisperse gold nanoparticle bipyramid for electrochemical dopamine sensor.

We demonstrated potential features of gold nanoparticle bipyramid (AuNB) for an electrochemical biosensor. The facile synthesis method and controllable shape and size of the AuNB are achieved through the optimization of cetyltrimethylammonium chloride (CTAC) surfactant over citric acid (CA) ratio determining the control of typically spherical Au seed size and its transition into a penta-twinned crystal structure. We observe that the optimized ratio of CTAC and CA facilitates flocculation control in which Au seeds with size as tiny as ∼14.

Versatile and Low-Cost Fabrication of Modular Lock-and-Key Microfluidics for Integrated Connector Mixer Using a Stereolithography 3D Printing.

We present a low-cost and simple method to fabricate a novel lock-and-key mixer microfluidics using an economic stereolithography (SLA) three-dimensional (3D) printer, which costs less than USD 400 for the investment. The proposed study is promising for a high throughput fabrication module, typically limited by conventional microfluidics fabrications, such as photolithography and polymer-casting methods. We demonstrate the novel modular lock-and-key mixer for the connector and its chamber modules with optimized parameters, such as exposure condition and printing orientation.

Metal-Organic-Framework FeBDC-Derived FeO for Non-Enzymatic Electrochemical Detection of Glucose.

Present-day science indicates that developing sensors with excellent sensitivity and selectivity for detecting early signs of diseases is highly desirable. Electrochemical sensors offer a method for detecting diseases that are simpler, faster, and more accurate than conventional laboratory analysis methods. Primarily, exploiting non-noble-metal nanomaterials with excellent conductivity and large surface area is still an area of active research due to its highly sensitive and selective catalysts for electrochemical detection in enzyme-free sensors.