Publications by authors named "Isınsu Alkan"
Aim: Gamma radiation, a form of ionizing radiation, is used in many different areas, especially in the health field and in the treatment of cancer. However, gamma radiation used for therapeutic purposes also has numerous harmful effects on human health. This study was planned to investigate the impacts of exposure to gamma radiation on the hippocampal area and the preventive effects of myricitrin and chebulinic acid against that damage.
View Article and Find Full Text PDFPolycystic ovarian syndrome (PCOS) is frequently observed in adolescent women and usually progresses with depression. The aim of this study was to examine the effects of amitriptyline (Ami), a drug used in the treatment of depression, in individuals with PCOS. Forty 12-week-old female Wistar albino rats were randomly divided into five groups: control, sham, PCOS, Ami, and PCOS + Ami.
View Article and Find Full Text PDFAim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; non-obese control (NOC) obese control (OC), non-obese injury (NOH), obese injury (OH), non-obese adipose (NOY), obese adipose (OY), non-obese nerve (NOPS), obese nerve (OPS). At the end of 8 weeks, all experimental animals without control groups were subjected to nerve crush procedure and sciatic nerve or fat stem cell homogenates were injected on the treatment group rats, and then, recovery process has been observed and histopathological, stereological, electrophysiological analyses and bioinformatic evaluation were made on removed sciatic nerves.
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- Obesity, driven by high-fat diets, is linked to memory issues, prompting a study on its effects on the hippocampus using various scientific methods.
- Female rats were divided into control and high-fat diet groups, with the latter receiving a high-fat intake for two months before analysis of brain and blood samples.
- Results showed a decrease in neuron count and significant damage to the hippocampal structure in the high-fat diet group, with increased oxidative stress and altered levels of proteins associated with neuron health and memory.
Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fat). After nine weeks, the rats were allowed to recover for 4 weeks in INH group.
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- The study aimed to investigate curcumin's effects on the kidneys of diabetic rats, as diabetes and kidney diseases are becoming more prevalent globally.
- Thirty-five female Wistar albino rats were used, divided into various groups, where one group received curcumin treatment after diabetes was induced, while others served as controls or received different treatments.
- Results showed that curcumin demonstrated a protective effect on kidney structures, particularly in the glomerulus, indicating its potential for mitigating kidney damage in diabetic conditions.
The radiation emitted from mobile phones has various deleterious effects on human health. This study was conducted to evaluate the effects of exposure to the 900-MHz radiation electromagnetic fields (EMF) emitted by mobile phones on Ammon's horn and the dentate gyrus (DG) in the hippocampus and cerebellum of male albino rats. We also investigated the neuroprotective effects of the antioxidants (BS) and folic acid (FA) against exposure to EMF.
View Article and Find Full Text PDFTechnological devices have become essential components of daily life. However, their deleterious effects on the body, particularly on the nervous system, are well known. Electromagnetic fields (EMF) have various chemical effects, including causing deterioration in large molecules in cells and imbalance in ionic equilibrium.
View Article and Find Full Text PDFObjective: The aim of the present study is to investigate the effects of topiramate on the fat mass/obesity-associated protein (FTO) and on the neuropeptide Y (NPY) level in the hypothalamus depending on the recently increased prevalence of obesity.
Method: In this study, twenty-four female rats were divided into four equal groups: Non-obese control, obese control, non-obese topiramate, and obese topiramate. Obese groups were fed with a 40% high-fat diet.