Evaluation of Surgical Antimicrobial Prophylaxis Compliance: A Multicentre Point Prevalence Study.

Background: This study aimed to determine the frequency of compliance with surgical prophylaxis in Turkey and to identify the causes and risk factors for non-compliance.

Methods: This multi-center, prospective, point prevalence study was conducted in eight hospitals from different regions of Turkey. Patients over 18 years who underwent surgical antimicrobial prophylaxis (SAP) in all hospital surgical units were included in the study.

Enantioselective Addition of 1,3,5,7-Tetramethyl-BODIPYs to Isatins by Bifunctional Quinine-Based Squaramides.

This work describes the development of the first enantioselective addition reaction between 1,3,5,7-tetramethyl-BODIPYs and isatin derivatives. The reaction utilizes bifunctional quinine/squaramide organocatalysts and affords nine novel chiral BODIPY dyes under mild conditions, with enantioselectivities reaching up to 60%. The synthesized BODIPY-oxindoles exhibit high fluorescence emissions, consistent with their parent BODIPYs, and display tunable colors.

Two sides of the same coin-sexuality from the perspective of women diagnosed with breast cancer and their partners: A qualitative study.

Purpose: After the diagnosis of breast cancer, women's sexuality becomes complex, and the sexual lives of couples are strongly affected by the treatment process of the disease. The aim of this study is to determine the perceptions, experiences, expectations, and needs related to sexuality from the perspective of women diagnosed with breast cancer and their partners.

Method: In this study, a descriptive qualitative design based on a thematic analysis approach was used.

The importance of targeted next-generation sequencing based genomic profiling in the diagnosis of childhood acute myeloid leukemia: a single center experience.

Background: The management of pediatric acute myeloid leukemia (AML) is based on the prognostic risk classification of initial leukemia. Targeted next-generation sequencing (NGS) is a reliable method used to identify recurrently mutated genes of pediatric AML and associated prognosis.

Methods: In this study, we retrospectively evaluated the prognostic, and therapeutic utility of a targeted NGS panel covering twenty-five genes, in 21 children with de novo and 8 with relapsed or secondary AML.

The effect of coronavirus disease perception on somatic sensations and cognitive emotion regulation in pregnant women.

The objective of this study was to evaluate the effect of coronavirus disease perception on somatic sensations and cognitive emotion regulation in pregnant women. The study is a descriptive cross-sectional study. The sample consisted of 144 pregnant women.

Impact of Aspergillus PCR on the management of invasive aspergillosis: A tertiary care hospital experience during the COVID-19 pandemic.

Aim: To assess the impact of Aspergillus PCR on managing invasive aspergillosis (IA) in routine patient management.

Methods: A retrospective study included 235 patients who had Aspergillus PCR tests performed on respiratory samples (bronchoalveolar lavage, non-bronchoscopic lavage, and sputum) from November 2020 to April 2022.

Results: Of 293 tests, 11.

Could "Sub-RPE illumination" be a prognostic marker? A prospective dry AMD study.

Purpose: To evaluate the natural history of dry age-related macular degeneration (AMD) through advanced retinal pigment epithelium (RPE) analysis and sub-RPE illumination (SRI) data and to elucidate their correlation with disease progression.

Methods: A total of 82 patients with dry AMD were included in this longitudinal study. Spectral-domain optical coherence tomography (SD-OCT) was utilized to evaluate central macular thickness (CMT), central retinal thickness (CRT), foveal outer nuclear layer (ONL) thickness, and ellipsoid zone (EZ) integrity.

Multicomponent synthesis of stereogenic-at-boron fluorophores (BOSPYR) from boronic acids, salicylaldehydes, and 2-formylpyrrole hydrazones.

This work describes one-step syntheses of various stereogenic-at-boron fluorochromes (BOSPYR) multicomponent reactions involving readily accessible boronic acids, salicylaldehydes, and 2-formylpyrrole hydrazones. The dyes absorb and emit in the visible region of the electromagnetic radiation, and are characterized by large Stokes shifts (2850-4930 cm) with weak fluorescence emissions (: 1.5-9.

Gynecology and obstetrics patients' attitudes towards body privacy: A cross-sectional-descriptive study.

Objective: It is extremely important for healthcare professionals to protect patients' privacy during diagnosis and treatment processes related to gynecology and obstetrics and to warn them in case patients' privacy is violated. This study was aimed at determining attitudes of female patients having obstetrics examination towards privacy and raising their awareness of privacy.

Methods: This cross-sectional-descriptive study was conducted with 410 patients who presented to the gynecology and obstetrics outpatient clinic of a university hospital.

CRISPR-Cas9-mediated genome editing delivered by a single AAV9 vector inhibits HSV-1 reactivation in a latent rabbit keratitis model.

Herpes simples virus 1 (HSV-1) keratitis is a major cause of blindness globally. During primary infection, HSV-1 travels to the trigeminal ganglia and establishes lifelong latency. Although some treatments can reduce symptom severity and recurrence, there is no cure for HSV-1 keratitis.

Effect of different obturation techniques on treatment results in single-visit non-surgical endodontic retreatment: randomized controlled clinical study.

Background: Evaluating the effect of different obturation techniques on postoperative pain level and radiographic healing on non-surgical endodontic retreatment (NSER) applied in a single visit in teeth with a single root canal and apical periodontitis (AP).

Materials And Methods: Sixty-three teeth from 50 systemically healthy patients (mean age 34.19 ± 9.

One-Year Outcomes of Aflibercept in Treat-and-Extend Versus Pro Re Nata Regimens for Bevacizumab-Resistant Diabetic Macular Edema: A Real-World Study.

Introduction: The aim of this study was to compare the efficacy of the treat-and-extend (TAE) regimen versus the pro re nata (PRN) regimen in patients with bevacizumab-resistant diabetic macular edema (DME) treated with aflibercept, with or without adjunctive laser therapy.

Methods: Ninety-one eyes from 91 patients who were switched to aflibercept after three consecutive intravitreal bevacizumab injections for the treatment of DME were included in this retrospective real-world study. The patients were categorized into three groups: TAE (n = 30), TAE + laser (n = 31), and PRN (n = 30).

Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing.

Cellular growth and organismal development are remarkably complex processes that require the nutrient-responsive kinase mechanistic target of rapamycin complex 1 (mTORC1). Anticipating that important mTORC1 functions remained to be identified, we employed genetic and bioinformatic screening in C. elegans to uncover mechanisms of mTORC1 action.

Blood component-associated acute transfusion reactions in pediatric patients: experience of a tertiary care hospital.

Background/aim: The transfusion of blood products is a life-saving clinical practice in patients with bleeding, hemoglobinopathy, and cancer. It was aimed herein to analyze the frequency and types of blood component-related acute transfusion reactions (ATRs) in pediatric patients.

Materials And Methods: This retrospective study was conducted at a tertiary care academic pediatric hospital.

Synthesis, α-Glucosidase, α-Amylase, and Aldol Reductase Inhibitory Activity with Molecular Docking Study of Novel Imidazo[1,2-]pyridine Derivatives.

Inhibition ofaldose reductase (AR), α-glycosidase (α-GLY), and α-amylase (α-AMY) are some of the essential targets in diabetes mellitus (DM). Here, a series of imidazo[1,2-]pyridine-based 1,3,4-thiadiazole derivatives (-) were successfully synthesized and characterized using H NMR, C NMR, and HRMS spectroscopic techniques. The inhibition effects of the synthesized derivatives against AR, α-GLY, and α-AMY were evaluated using both in vitro and in silico methods.

Interactions of novel 1,3-diaryltriazene-sulfamethazines with carbonic anhydrases: Kinetic studies and in silico simulations.

Sulfonamides, recognized as carbonic anhydrase (CA, EC 4.2.1.

Frequency of Post Traumatic Stress Disorder and Associated Factors Among Survivors of Van Avalanche: 6-Month Follow-up Study.

Objective: We aimed to evaluate the frequency of Post Traumatic Stress Disorder (PTSD), to determine the risk factors, and to monitor the change of symptoms after 6 months among individuals who survived the avalanche disaster in Van.

Method: Face-to-face interviews were conducted with 35 people who were rescued from two consecutive avalanche disasters in Van 2 months and 6 months after the avalanche disaster. The socio-demographic and clinical data of the cases were evaluated.

Osseous metastases of uterine leiomyosarcoma: Analysis of survival & surgical management.

Background: Uterine leiomyosarcoma represents a seldom-encountered subset within the spectrum of uterine malignancies. Occurrences of appendicular skeletal metastases in uterine leiomyosarcomas are infrequent. In this study, we examined patient surveys to elucidate the clinical characteristics and outcomes of individuals with uterine leiomyosarcoma exhibiting metastatic dissemination to these anatomical regions.

Confounding giant right atrial mass.

Background: Primary cardiac tumors are uncommon, with approximately 70-80% classified as benign. Myxomas constitute roughly half of all benign cardiac tumors, while cardiac hydatid cysts are exceptionally rare. Shortness of breath is a prominent symptom associated with these conditions.

Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic enzymes.

In contemporary medicinal chemistry, employing a singular small molecule to concurrently multi-target disparate molecular entities is emerging as a potent strategy in the ongoing battle against metabolic disease. In this study, we present the meticulous design, synthesis, and comprehensive biological evaluation of a novel series of 1,2,3-triazolylmethylthio-1,3,4-oxadiazolylbenzenesulfonamide derivatives (8a-m) as potential multi-target inhibitors against human carbonic anhydrase (EC.4.