An update on pathogenesis and clinical scenario for Parkinson's disease: diagnosis and treatment.

In severe cases, Parkinson's disease causes uncontrolled movements known as motor symptoms such as dystonia, rigidity, bradykinesia, and tremors. Parkinson's disease also causes non-motor symptoms such as insomnia, constipation, depression and hysteria. Disruption of dopaminergic and non-dopaminergic neural networks in the substantia nigra pars compacta is a major cause of motor symptoms in Parkinson's disease.

Sensitivity and Specificity of Non-Invasive Blood Glucose Level Measurement Optical Device to Detect Hypoglycaemia.

Hypoglycemia is related to lethargy, psychiatric disorders, and impaired brain metabolism. Hypoglycemia is one of the leading factors of death in blood glucose level (BGL) metabolism disorders. Optical methods have been heavily researched due to its potential to eliminate drawbacks of conventional hypoglycemia detection; however, clinical data are still scarce.

A Coupled Phase-Temperature Model for Dynamics of Transient Neuronal Signal in Mammals Cold Receptor.

We propose a theoretical model consisting of coupled differential equation of membrane potential phase and temperature for describing the neuronal signal in mammals cold receptor. Based on the results from previous work by Roper et al., we modified a nonstochastic phase model for cold receptor neuronal signaling dynamics in mammals.