, , ASSOСIATION BETWEEN VITAMIN D STATUS AND METABOLIC DISORDERS IN PREMENOPAUSAL WOMEN WITH AUTOIMMUNE HYPOTHYROID DISEASE.

Objective: The aim: Is to establish a relationship between serum vitamin D level with carbohydrate and lipid indexes in women with autoimmune hypothyroid disease.

Patients And Methods: Materials and methods: 146 women with autoimmune hypothyroid disease were examined in the period 2017-2019, who signed the informed consent. The mean age of women was 43.

Diagnostic chemoresistant mycobacterium tuberculosis in the ternopil region of Ukraine.

Objective: The aim: To analyze the changes in indicators of tuberculosis mycobacteria sensitivity to anti-mycobacterial drugs over the past nine years in Ternopol region (Ukraine) and to develop recommendations for the use of drug combinations in this region.

Patients And Methods: Materials and methods: The medical examinations were carried out in the Clinical and Diagnostic Laboratory of Ternopil Regional Tuberculosis Hospital during 2007-2017. Sensitivity analysis was carried out on a solid Löwenstein-Jensen medium and in liquid Meedlebrook medium using automatic bacteriological BACTEC 1443 tests with addition to the media of first line anti-TB drugs.

Ultrastructural liver changes in the experimental thyrotoxicosis.

Aim of the study is to evaluate ultrastructural changes of rat liver in experimental thyrotoxicosis. For the study, 36 male rats have been utilized, weighing approximately 150-190 g, which were divided into three groups: the first, control group (12 animals) was composed of healthy rats that received intragastric sodium chloride 0.9% solution, the second group (12 animals) - animals with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 2 weeks, and the third group (12 animals) - rats with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 4 weeks.