Publications by authors named "Iryna P Kotlyar"
Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate.
ScientificWorldJournal
November 2017
Article Synopsis
- The protein kinase inhibitor MI-1 showed promising anti-inflammatory effects in a rat model of acetic acid-induced ulcerative colitis, outperforming the reference drug Prednisolone in reducing tissue damage.
- After 14 days of treatment, MI-1 significantly improved colon mucosa integrity, with a grade of total injury (GTI) falling to 0.5 compared to 3 for Prednisolone.
- Additionally, MI-1 effectively normalized oxidative stress markers in the bowel, suggesting its potential for treating inflammatory diseases better than current standard therapies.
Introduction: Pyrrol derivate 5-amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one (D1) has shown antiproliferative activities in vitro, so investigation of the impact of D1 intake on gut organs in rats that experienced colon cancer seems to be necessary.
Materials And Methods: D1 at the dose of 2.3 mg/kg was administered per os daily for 27 (from the 1st day of experiment) or 7 (from the 21st week of experiment) weeks to rats that experienced 1,2-dimethylhydrazine (DMH)-induced colon cancer for 20 weeks.