Publications by authors named "Iryna Kovtun"
Article Synopsis
- A specific group of dormant hematopoietic stem cells (dHSCs) acts as a reserve pool to protect against exhaustion, but too much dormancy can hinder responses to blood system stress.
- Researchers discovered that CD38 serves as a key marker for identifying dHSCs and found that the cADPR signaling pathway, regulated by CD38, plays a crucial role in maintaining dHSC dormancy by influencing a protective cell cycle inhibitor.
- Understanding this CD38/cADPR/Ca2+/c-Fos/p57Kip2 pathway could lead to new methods to enhance stem cell transplant effectiveness and promote blood recovery post-injury or illness.
