Publications by authors named "Iryna Horak"
Article Synopsis
- Berberine alkaloids, a type of isoquinoline alkaloids, have shown potential in inhibiting breast cancer development, but their exact mechanisms of action remain unclear.
- These compounds were found to suppress breast cancer cell proliferation, migration, and invasion through various assays, and they induced apoptosis via intrinsic and extrinsic pathways.
- The results indicated that these alkaloids affect the Wnt/β-catenin signaling pathway and epithelial to mesenchymal transition (EMT), with different effects on breast cancer cell lines, suggesting their potential for breast cancer treatment.
Effective targeting of metastasis is considered the main problem in cancer therapy. The development of herbal alkaloid Berberine (Ber)-based anticancer drugs is limited due to Ber' low effective concentration, poor membrane permeability, and short plasma half-life. To overcome these limitations, we used Ber noncovalently bound to C fullerene (C).
View Article and Find Full Text PDFCisplatin (Cis-Pt) is the cytotoxic agent widely used against tumors of various origin, but its therapeutic efficiency is substantially limited by a non-selective effect and high toxicity. Conjugation of Cis-Pt with nanocarriers is thought to be one option to enable drug targeting. The aim of this study was to estimate toxic effects of the nanocomplex formed by noncovalent interaction of C fullerene with Cis-Pt against Lewis lung carcinoma (LLC) cells in comparison with free drug.
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