Publications by authors named "Iryna B Romash"
Article Synopsis
- - The research aimed to analyze how the functionality of the glutathione system changes over time in individuals with paranoid schizophrenia, focusing on the activities of specific glutathione-dependent enzymes based on how long the patients have had the illness.
- - A total of 300 patients were divided into five groups based on the duration of their illness, with findings showing a significant decrease in the activity of key enzymes like glutathione peroxidase and glutathione reductase, especially pronounced in those with 3-5 years of illness.
- - The study highlights critical periods of glutathione system inhibition, suggesting important implications for future treatments in managing paranoid schizophrenia.
Objective: Aim: To analyse laboratory and biochemical features of the severe persistent course of asthma in patients with undifferentiated connective tissue dysplasia (UCTD) syndrome, and their phenotypic and visceral stigmas of dysembryogenesis.
Patients And Methods: Materials and Methods: We enrolled 60 male patients with asthma, aged from 23 to 62 years (mean age (46.83 ±0.
Objective: The aim: The objective of the research was to study the indicators of oxidative modification of proteins (OMP) and the activity of matrix metalloproteinase-9 (MMP-9) in patients with paranoid schizophrenia depending on the disease duration.
Patients And Methods: Materials and methods: 320 patients were included in the examination. 20 patients were with "Primary psychotic episode" (Comparison Group) and 300 patients were diagnosed with "Paranoid schizophrenia" (Experimental Group): 60 of them have suffered from this disease for a duration from 3 to 5 years (Subgroup I ); 60 patients have suffered for a period from 6 to 10 years (Subgroup II); 60 individuals - from 11 to 15 years (Subgroup III); 60 patients have suffered for a duration from 16 to 20 years (Subgroup IV); 60 patients - from 21 years and longer (Subgroup V).
Objective: Aim: To study the role of certain neurotransmitters (brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT)), metalloenzymes (matrix met-alloproteinase-9) (MMP-9) and hormones (ghrelin) in the pathogenesis of mental disorders associated with stress under the impact of traumatic events.
Patients And Methods: Materials and methods: We conducted a systematic search of major electronic medical databases published before October 1, 2022. Such keywords as (post-traumatic stress disorder OR PTSD), (Brain-derived neurotrophic factor OR BDNF), (matrix metalloproteinase-9 OR MMP-9), (serotonin OR 5-HT), ghrelin, melatonin identified relevant studies.
Objective: The aim: To study the features of social dysfunction, assess the levels of social frustration and satisfaction with the quality of medical care in patients with schizophrenia on the background of somatic comorbidity.
Patients And Methods: Materials and methods: The study included 105 patients (55 women - 52.38% and 50 men - 47.
Objective: The aim of the study was to discover the interrelation between the severity of gastroesophageal reflux disease (GERD) symptoms, acid exposure time (AET), excessive daytime sleepiness (EDS) and the level of active blood plasma ghrelin in the patients with undifferentiated connective tissue disease (UCTD).
Patients And Methods: Materials and methods: The study included 120 patients with GERD. All the patients were divided in two groups: Group I - GERD was not accompanied by the signs of connective tissue disease (n=45) and Group II - GERD developed on the background of UCTD syndrome (n=75).
Objective: The aim: To review the biopsychosocial aspects of psychiatric comorbidity in patients with musculoskeletal conditions and recommend a relevant mental health action plan.
Patients And Methods: Materials and methods: Keywords (orthopedics, psychiatry, mental health) were used to list down and analyze the literature in PubMed and Google Scholar. All types of articles, including original research, systematic reviews, and meta-analyses, along with gray literature dating back to 2000.
Objective: The aim: To develop the key principles of psychohygienic improvement of the processes of personality formation and enhancement of the quality of life of pupils and students of modern educational institutions of various types.
Patients And Methods: Materials and methods: While working out the basic principles of psychohygienic correction of the processes of personality development and improvement of the quality of life of pupils and students of modern educational institutions of various types, we have conducted surveys of the adolescent boys and girls studying at five modern educational institutions in Ivano-Frankivsk city, namely Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk Finance Commercial Cooperative College named after Stepan Hranat, Ivano-Frankivsk State Music School named after Denys Sichynskyi, Ivano-Frankivsk Vocational Lyceum of Road Transport and Construction No. 15, and Ivano-Frankivsk Boarding Lyceum for Gifted Young People from Rural Areas.
Objective: The aim: The aim of the research was to study the prevalence of visceral and phenotypic markers of UCTD syndrome in patients with GERD for the purpose of early diagnosis of this comorbidity.
Patients And Methods: Materials and methods: The study included 120 patients: 75 patients (Group II) - GERD was on the background of UCTD, 45 (Group I ) - the patients with GERD. The average age of the patients was 42.