Comparison Between Pregabalin and Sertraline in the Treatment of Uremic Pruritus in Patients With Maintenance Hemodialysis.

Introduction Pruritus, a medical symptom also known as itch, is characterized by an unpleasant feeling coupled with the urge to scratch. Patients with chronic kidney disease (CKD) often have symptoms of pruritus due to uremia, which has adversely affected their quality of life. The treatment protocol for CKD pruritus is still being debated due to its unclear etiopathogenesis.

Unconventional role of Rab4 in the secretory pathway in Leishmania.

Leishmania donovani is an auxotroph for heme. Parasite acquires heme by clathrin-mediated endocytosis of hemoglobin by specific receptor. However, the regulation of receptor recycling pathway is not known in Leishmania.

Acanthosis nigricans independently predicts hepatic fibrosis in people with type 2 diabetes in North India.

Background: Acanthosis nigricans (AN) is a skin condition characterized by hyperpigmentation and thickening, often found in individuals with insulin resistance. Despite this well-established association, the potential link between AN and hepatic fibrosis in people with type 2 diabetes (T2D) has yet to be thoroughly explored.

Methodology: We recruited a total of 300 people with T2D, half of whom had AN (n, 150), and the other half without AN (n, 150).

Machine learning based multipurpose medical image watermarking.

Digital data security has become an exigent area of research due to a huge amount of data availability at present time. Some of the fields like medical imaging and medical data sharing over communication platforms require high security against counterfeit access, manipulation and other processing operations. It is essential because the changed/manipulated data may lead to erroneous judgment by medical experts and can negatively influence the human's heath.

Hemoglobin Endocytosis and Intracellular Trafficking: A Novel Way of Heme Acquisition by .

species are causative agents of human leishmaniasis, affecting 12 million people annually. Drugs available for leishmaniasis are toxic, and no vaccine is available. Thus, the major thrust is to identify new therapeutic targets.

Dapagliflozin Improves Body Fat Patterning, and Hepatic and Pancreatic Fat in Patients With Type 2 Diabetes in North India.

Context: Excess hepatic and pancreatic fat may contribute to hyperglycemia.

Objective: The objective of this study was to examine the effect of dapagliflozin (an SGLT2 inhibitor) on anthropometric profile, liver, and pancreatic fat in patients with type 2 diabetes mellitus (T2DM).

Methods: This is an observational interventional paired study design without a control group.

Multipurpose medical image watermarking for effective security solutions.

Digital medical images contain important information regarding patient's health and very useful for diagnosis. Even a small change in medical images (especially in the region of interest (ROI)) can mislead the doctors/practitioners for deciding further treatment. Therefore, the protection of the images against intentional/unintentional tampering, forgery, filtering, compression and other common signal processing attacks are mandatory.

High prevalence of hepatic steatosis and hepatic fibrosis in patients with type 2 diabetes mellitus.

Aim: To determine the prevalence of hepatic steatosis and fibrosis in patients with T2DM from North India.

Research Design And Methods: In this cross-sectional study, Asian Indian patients with T2DM (n,250) underwent liver ultrasonography (USG), Fibroscan for assessment of hepatic steatosis (Controlled Attenuation Parameter, CAP) and hepatic fibrosis (Kilopascals, kPa) respectively. Pearson's correlation analysis & logistic regression analysis for significant predictors of hepatic steatosis and fibrosis were done.

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study.

Background: Post COVID-19 syndrome (PCS) has emerged as a major roadblock in the recovery of patients infected with SARS-CoV-2. Amongst many symptoms like myalgia, headache, cough, breathlessness; fatigue is is most prevalent and makes the patient severely debilitated. Research on PCS, in particular fatigue, in patients with diabetes has not been done.

Identification and characterization of the hemoglobin-binding domain of hemoglobin receptor in Leishmania.

Leishmania internalize hemoglobin (Hb) via a specific receptor (HbR) for their survival. To identify the Hb-binding domain of HbR, we cloned and expressed several truncated proteins of HbR and determined their ability to bind Hb. Our findings reveal that 90% of Hb-binding activity is retained in HbR in comparison with HbR .

Rab5b function is essential to acquire heme from hemoglobin endocytosis for survival of Leishmania.

Previously, we showed that Rab5a and Rab5b differentially regulate fluid-phase and receptor-mediated endocytosis in Leishmania, respectively. To unequivocally demonstrate the role of Rab5b in hemoglobin endocytosis in Leishmania, we generated null-mutants of Rab5b parasites by sequentially replacing both copies of LdRab5b with the hygromycin and neomycin resistance gene cassettes. LdRab5b null-mutant parasite was confirmed by qPCR analysis of genomic DNA using LdRab5b specific primers.