Publications by authors named "Irmgard Diepolder"
Schwann cells (SCs) are essential in the production of the axon-wrapping myelin sheath and provide trophic function and repair mechanisms in the peripheral nerves. Consequently, well-characterized SC in vitro models are needed to perform preclinical studies including the investigation of the complex biochemical adaptations occurring in the peripheral nervous system (PNS) under different (patho)physiological conditions. MSC80 cells represent a murine SC line used as an in vitro system for neuropathological studies.
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- The study investigates the role of GIP (glucose-dependent insulinotropic peptide) in atherosclerotic cardiovascular disease, noting its relationship with peripheral artery disease (PAD), where higher GIP levels were found in patients with PAD compared to those without.
- Researchers conducted experiments on ApoE mice to explore GIP's effects; GIP overexpression led to reduced macrophage infiltration in atherosclerotic plaques and enhanced plaque stability without changing overall plaque size.
- The findings suggest GIP may improve cardiovascular outcomes by decreasing inflammation and monocyte migration, pointing to its potential benefits beyond glucose control.
Neuromuscular junctions (NMJs) are synapses that transmit impulses from motor neurons to skeletal muscle fibers leading to muscle contraction. Study of hereditary disorders of neuromuscular transmission, termed congenital myasthenic syndromes (CMS), has helped elucidate fundamental processes influencing development and function of the nerve-muscle synapse. Using genetic linkage, we find 18 different biallelic mutations in the gene encoding glutamine-fructose-6-phosphate transaminase 1 (GFPT1) in 13 unrelated families with an autosomal recessive CMS.
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