Publications by authors named "Irmak Kaysudu"
Article Synopsis
- PTEN and PIK3CA mutations are common in several cancers and loss of PTEN leads to increased activity of the p110β isoform of the PI3K pathway.
- The study found that the enzyme SQLE, important for cholesterol production, is upregulated in PTEN-deficient prostate tumors, and its levels are connected with PI3K activation.
- Targeting cholesterol biosynthesis alongside hormone receptor signaling may enhance treatment effectiveness for hormone-resistant prostate and breast cancers that lack PTEN.
