Publications by authors named "Irma Tedja"

Background And Aim: Antimicrobial resistance is an emerging public health threat. Foodborne illnesses are typically caused by bacteria, such as , , , and , which are frequently resistant to common antimicrobial agents. Rice is a staple grain in most parts of the world.

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Background And Aim: Fungal zoonoses are an economic and public health concern because they can cause various degrees of morbidity and mortality in animals and humans. To combat this issue, alternative natural antifungals, such as products derived from rice protein hydrolysates or rice antifungal protein/peptide are being considered because they are highly bioactive and exhibit various functional properties. Thailand is a leading rice producer and exporter.

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Article Synopsis
  • Macrophages infected with Candida auris show metabolic changes, increasing glycolysis but not producing a strong immune response (IL-1β) or stopping the growth of the pathogen.
  • C. auris can evade the immune system by using its own metabolism to thrive and kills macrophages through metabolic stress caused by glucose starvation.
  • The pathogen does not activate the NLRP3 inflammasome, leading to low inflammatory responses, indicating that targeting metabolism in both host and pathogen could offer new treatment options for C. auris infections.
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Aspartyl proteases are a widely represented class of proteolytic enzymes found in eukaryotes and retroviruses. They have been associated with pathogenicity in a range of disease-causing microorganisms. The dimorphic human-pathogenic fungus Talaromyces marneffei has a large expansion of these proteases identified through genomic analyses.

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