Publications by authors named "Iritani S"
Article Synopsis
- - The study investigates the link between rare copy number variations (CNVs) in synaptic genes and bipolar disorder (BD) in a Japanese population, using genome hybridization techniques on nearly 2,000 BD patients and 2,760 controls.
- - Results indicate a strong association between the RNF216 gene and BD, with significant findings also related to postsynaptic membrane components, suggesting these genetic factors contribute to BD risk.
- - The findings enhance understanding of BD's genetic underpinnings, highlighting the importance of CNVs in gene regions that may influence the disorder's development.
Article Synopsis
- The study investigates why older patients with schizophrenia might be prone to developing dementia, despite previous findings suggesting their Alzheimer's disease risk is similar to those without schizophrenia.
- It involved an examination of 32 brains from older schizophrenia patients to analyze dementia-related neuropathologies and compare clinicopathological differences between those with and without dementia.
- The results revealed two subgroups of dementia in these patients: those with known neurodegenerative diseases and those without identifiable pathology, indicating a need for more thorough research on this issue.
Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson's r = -0.
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- * The median overall survival (OS) was 12.5 months, while the progression-free survival (PFS) was 5.4 months, with a notable 71.4% disease control rate, although most patients experienced adverse effects.
- * Significant changes in clinical indicators, specifically worsening ALBI scores and decreasing PIVKA-II levels, were found to correlate with overall survival outcomes, indicating that these factors could influence patient prognosis after treatment.
A case of drug-induced acute liver failure caused by corticosteroids.
Clin J Gastroenterol
October 2022
Article Synopsis
- A 61-year-old man treated with betamethasone for sudden deafness developed high fever and abnormal liver function tests shortly after starting the medication.
- After multiple hospitalizations and a tentative diagnosis of autoimmune hepatitis, he faced liver dysfunction and underwent plasma exchange due to acute liver failure.
- The case highlights the rarity of drug-induced liver injury from corticosteroids and emphasizes the importance of timely treatment for successful recovery.
A 76-year-old woman with advanced pancreatic cancer developed recurrent cholecystitis after covered self-expandable metal stent (CSEMS) placement. The cholecystitis was refractory to repeated percutaneous transhepatic gallbladder drainage (PTGBD). Cholecystography showed a patent cystic duct with right and cranial side bifurcation, which is indicative of an increased likelihood of success of endoscopic transpapillary gallbladder drainage (ETGBD).
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- The study investigates the differences and similarities in copy number variations (CNVs) related to bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD) using data from 8708 Japanese individuals.
- It reveals that BD has a greater burden of smaller exonic deletions, while SCZ and ASD show a prevalence of larger exonic CNVs, with notable differences in the effect sizes and distributions of these CNVs across disorders.
- Despite these differences, some shared molecular mechanisms, particularly in chromatin biology, were identified, and certain synaptic genes were linked to BD risk, suggesting potential pathways for further research into its causes.
Background: Zinc deficiency is likely to occur in chronic liver disease. The aim of this study was to determine the prevalence of zinc deficiency in different types of chronic liver disease and to identify the factors that predicted low serum zinc levels.
Methods: The study was an observational single-center design.
Neuropathological investigation of patients with prolonged anorexia nervosa.
Psychiatry Clin Neurosci
May 2022
Objectives: Recent neuroimaging studies have indicated that the mesolimbic pathway, known to work as reward neuronal circuitry, regulates cognitive-behavioral flexibility in prolonged anorexia nervosa (AN). Although AN is associated with the highest mortality rate among psychiatric disorders, there have been few neuropathological studies on this topic. This study aims to identify alterations of the reward circuitry regions, especially in the nucleus accumbens (NAcc), using AN brain tissues.
View Article and Find Full Text PDFA cold-water extract of olive leaves ( L.) is useful as a texture-improving agent for food protein gels. In this work, the compound contributing to the improvement of gel properties was investigated by using the egg white gel (EWG) as a model for food protein gels.
View Article and Find Full Text PDFObjective The relationship between the prognosis and magnitude of a decrease in tumor blood flow according to estimated tumor differentiation remains unclear. This study investigated the relationship between reductions in the rate of mean computed tomography (CT) attenuation values and the clinical prognosis. Methods We evaluated 63 consecutive patients who received lenvatinib treatment for unresectable hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFPiccolo, a presynaptic cytomatrix protein, plays a role in synaptic vesicle trafficking in the presynaptic active zone. Certain single-nucleotide polymorphisms of the Piccolo-encoding gene are reported to be associated with mental disorders. However, a few studies have evaluated the relationship between Piccolo dysfunction and psychotic symptoms.
View Article and Find Full Text PDFBackground And Aim: The aim of this study was to identify the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) as a predictor of overall prognosis in patients with hepatocellular carcinoma treated with lenvatinib.
Methods: Forty-eight consecutive patients who received lenvatinib treatment were reviewed. The oncological aggressiveness of tumors estimated using 18F-FDG-PET/CT was investigated by the analysis of progression-free survival (PFS), post-progression survival (PPS), and overall survival (OS).
Brain blood vessels constitute a micrometer-scale vascular network responsible for supply of oxygen and nutrition. In this study, we analyzed cerebral tissues of the anterior cingulate cortex and superior temporal gyrus of schizophrenia cases and age/gender-matched controls by using synchrotron radiation microtomography or micro-CT in order to examine the three-dimensional structure of cerebral vessels. Over 1 m of cerebral blood vessels was traced to build Cartesian-coordinate models, which were then used for calculating structural parameters including the diameter and curvature of the vessels.
View Article and Find Full Text PDFAnorexia nervosa (AN) is a serious eating disorder characterized by self-starvation and extreme weight loss. It has the highest mortality rate among all psychiatric disorders. Recent research indicates that malnutrition in AN patients induces various kinds of functional brain damage, but the pathophysiology of AN remains unclear.
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- GGT is a newly identified tauopathy characterized by globular accumulations of four-repeat tau proteins in both oligodendroglia and astrocytes, as well as neurons.
- A case study of a 79-year-old man with behavioral variant frontotemporal dementia (bvFTD) showed significant brain atrophy and inclusion of globular oligodendroglial inclusions, suggesting the presence of GGT Type I.
- The case highlights the complexity and potential overlap of GGT subtypes, particularly in relation to psychotic symptoms, indicating that subclassifying GGT can be challenging.
Article Synopsis
- - The study analyzes brain tissues from the superior temporal gyrus in schizophrenia and control cases, revealing significant differences in neuron structures across different brain areas.
- - It finds that the structural dissimilarity of neurons varies among individuals, particularly noting that neurite curvature and diameter are inversely related.
- - Schizophrenia cases exhibit a thinner and more complex neuronal network compared to controls, suggesting a link between neuron structure and the disorder, highlighting the individuality of brain functions.
Background: The aims of this study were to evaluate the efficacy of additional treatment, especially lenvatinib-transarterial chemoembolization (TACE) sequential therapy, for unresectable hepatocellular carcinoma (HCC).
Methods: Consecutive 56 patients who underwent lenvatinib treatment were reviewed. Oncological aggressiveness of tumor was estimated using a dynamic CT enhancement pattern classification, and clinical impact of subsequent treatment was investigated through analysis of progression-free survival (PFS), post-progression survival (PPS), and multivariate analysis of potential confounders for survival after progression during lenvatinib therapy.