Publications by authors named "Irisvan S Ribeiro"
In this study, we report the synthesis and characterization of pH-responsive nanoconjugates for targeted drug delivery. Galactomannan extracted from D. regia seeds was oxidized to form aldehyde groups, achieving a percentage of oxidation of 25.
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- Tree-exuded gums, particularly cashew gum from Anacardium trees in Brazil, are valuable natural polymers used in food and pharmaceuticals, known for their useful properties like hydro-solubility.
- Researchers aimed to enhance the properties of cashew gum by chemically modifying it through an amine reaction, which was verified using various analytical techniques, including NMR and infrared spectroscopy.
- The modification improved the gum's molar mass and thermal stability without inducing cytotoxic effects on macrophage cells at concentrations lower than 50.0 mg/L.
Stimulus-responsive nanoparticles stand out in studies for cancer treatment since these systems can promote a selective release of the drug in tumor tissues and cells, minimizing the effects caused by conventional chemotherapy. Dextran-graft-poly (N-isopropylacrylamide) copolymers were synthesized via Schiff base formation. The synthesis of copolymers was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (NMR) and the analyses of dynamic light scattering (DLS) showed that the copolymers were thermal and pH dual-responsive.
View Article and Find Full Text PDFPolysaccharide based copolymers have been the focus of several research, particularly for the development of drug delivery systems. This study reports on the preparation of nanoparticles from an amphiphilic copolymer obtained by the poly(ε-caprolactone) graft in the structure of cashew gum, via ring-opening polymerization. The synthesis of copolymers was confirmed by Fourier transform infrared spectroscopy and nuclear magnetic resonance.
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